UCSF

ZINC08780879

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Substance Information

In ZINC since Heavy atoms Benign functionality
July 27th, 2007 33 No

Popular Name: C 646 C 646

Find On: PubMed — Wikipedia — Google

CAS Number: 328968-36-1

Other Names:

C646

N/A

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.65 4.07 -80.4 0 9 -1 133 444.423 5 ↓

Vendor Notes

Note Type Comments Provided By
Target Histone Acetyltransferase Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
EP300-1-E Histone Acetyltransferase P300 (cluster #1 Of 2), Eukaryotic Eukaryotes 400 0.27 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
EP300_HUMAN Q09472 Histone Acetyltransferase P300, Human 400 0.27 Binding ≤ 1μM
EP300_HUMAN Q09472 Histone Acetyltransferase P300, Human 400 0.27 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Attenuation phase
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Factors involved in megakaryocyte development and platelet production
formation of the beta-catenin:TCF transactivating complex
HATs acetylate histones
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Polo-like kinase mediated events
PPARA activates gene expression
Pre-NOTCH Transcription and Translation
Regulation of gene expression by Hypoxia-inducible Factor
REV-ERBA represses gene expression
RORA activates circadian gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Transcriptional regulation of white adipocyte differentiation

Analogs ( Draw Identity 99% 90% 80% 70% )