UCSF

Histone Acetyltransferase P300, Human (8 Compounds)

Swissprot:
EP300_HUMAN
Stitch:
EP300_HUMAN
UniProt:
Q09472
ChEMBL:
CHEMBL3784
Reactome:
REACT_200624
REACT_111118
REACT_24941
REACT_160254
REACT_160243
REACT_24970
REACT_200753
REACT_172610
REACT_163743
REACT_118780
REACT_163910
REACT_1006
REACT_116145
REACT_118568
REACT_121092
REACT_118789
REACT_118659
REACT_25026
REACT_24938
REACT_27161
PDB:
1L3E (DOCK)
1P4Q (DOCK)
2K8F (DOCK)
3BIY (DOCK)
3I3J (DOCK)
3IO2 (DOCK)
3P57 (DOCK)
EP300

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 2 2 0
Binding ≤ 1μM 1 1 0 0

Reactome Network (20)

Reactome ID Description Species
REACT_200624 Attenuation phase Homo sapiens
REACT_111118 BMAL1:CLOCK,NPAS2 activates circadian gene expression Homo sapiens
REACT_24941 Circadian Clock Homo sapiens
REACT_160254 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
REACT_160243 Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
REACT_24970 Factors involved in megakaryocyte development and platelet production Homo sapiens
REACT_200753 formation of the beta-catenin:TCF transactivating complex Homo sapiens
REACT_172610 HATs acetylate histones Homo sapiens
REACT_163743 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Homo sapiens
REACT_118780 NOTCH1 Intracellular Domain Regulates Transcription Homo sapiens
REACT_163910 NOTCH2 intracellular domain regulates transcription Homo sapiens
REACT_1006 Polo-like kinase mediated events Homo sapiens
REACT_116145 PPARA activates gene expression Homo sapiens
REACT_118568 Pre-NOTCH Transcription and Translation Homo sapiens
REACT_121092 Regulation of gene expression by Hypoxia-inducible Factor Homo sapiens
REACT_118789 REV-ERBA represses gene expression Homo sapiens
REACT_118659 RORA activates circadian gene expression Homo sapiens
REACT_25026 TRAF3-dependent IRF activation pathway Homo sapiens
REACT_24938 TRAF6 mediated IRF7 activation Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3

formation of the beta-catenin:TCF transactivating complex

Uniprot Swissprot Chembl Description Number Shared
KAT5_HUMAN Q92993 CHEMBL5750 Histone Acetyltransferase KAT5, Human 1

HATs acetylate histones

Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3
KAT5_HUMAN Q92993 CHEMBL5750 Histone Acetyltransferase KAT5, Human 1

NOTCH1 Intracellular Domain Regulates Transcription

Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3

Pre-NOTCH Transcription and Translation

Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
EPAS1_HUMAN Q99814 CHEMBL1744522 Endothelial PAS Domain-containing Protein 1, Human 2 0 0 0
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 13 9 7 7
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 32 11 6 8
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 25 14 10 12
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 13 9 6 7
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 15 11 9 11
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 20 18 10 12
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin Type-A Receptor 7, Human 12 9 6 7
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 15 13 9 11
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 17 14 10 11
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 21 13 7 11
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 21 4 2 2
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 332 21 10 23
EPHB6_HUMAN O15197 CHEMBL5836 Ephrin Type-B Receptor 6, Human 4 4 3 4
EPOR_HUMAN P19235 CHEMBL1817 Erythropoietin Receptor, Human 3 0 0 0
EPYC_HUMAN Q99645 CHEMBL2080 Small Chondroitin/dermatan Sulfate Proteoglycan, Human 23 10 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
EP300-1-E Histone Acetyltransferase P300 (cluster #1 Of 2), Eukaryotic 6 2 2 0
EP300-2-E Histone Acetyltransferase P300 (cluster #2 Of 2), Eukaryotic 2 0 0 0
Uniprot Swissprot Chembl Description Number Shared
KAT2B_HUMAN Q92831 CHEMBL5500 Histone Acetyltransferase PCAF, Human 3
G3PG_TRYCR P22513 CHEMBL5926 Glyceraldehyde-3-phosphate Dehydrogenase, Glycosomal, Trycr 1
KAT5_HUMAN Q92993 CHEMBL5750 Histone Acetyltransferase KAT5, Human 1