| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 5th, 2005 | 11 | Yes |
Popular Name: 2s,4r-4-Methylglutamate 2s,4r-4-Methylglutamate
Find On: PubMed — Wikipedia — Google
CAS Number: 14561-55-8
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.77 | 2.23 | -73.7 | 3 | 5 | -1 | 108 | 160.149 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 2.29e+01 g/l | DrugBank-experimental |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1-3-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 310 | 0.83 | Binding ≤ 10μM |
| GRIK2-2-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 310 | 0.83 | Binding ≤ 10μM |
| GRIK3-2-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 310 | 0.83 | Binding ≤ 10μM |
| GRIK4-2-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 310 | 0.83 | Binding ≤ 10μM |
| GRIK5-2-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 310 | 0.83 | Binding ≤ 10μM |
| GRM1-4-E | Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 10000 | 0.64 | Functional ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.73 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 310 | 0.83 | Binding ≤ 1μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 310 | 0.83 | Binding ≤ 1μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 310 | 0.83 | Binding ≤ 1μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 310 | 0.83 | Binding ≤ 1μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 310 | 0.83 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 310 | 0.83 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 310 | 0.83 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 310 | 0.83 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 310 | 0.83 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 310 | 0.83 | Binding ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 10000 | 0.64 | Functional ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 2000 | 0.73 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events |
