UCSF

T-cell Surface Antigen CD4, Human (4 Compounds)

Swissprot:
CD4_HUMAN
Stitch:
CD4_HUMAN
UniProt:
P01730
ChEMBL:
CHEMBL2754
Reactome:
REACT_115574
REACT_6903
REACT_12555
REACT_12623
REACT_11166
REACT_19324
REACT_12582
REACT_12596
REACT_9031
PDB:
1CDH (DOCK)
1CDI (DOCK)
1CDJ (DOCK)
1CDU (DOCK)
1CDY (DOCK)
1G9M (DOCK)
1G9N (DOCK)
1GC1 (DOCK)
1JL4 (DOCK)
1OPN (DOCK)
1OPT (DOCK)
1OPW (DOCK)
1Q68 (DOCK)
1RZJ (DOCK)
1RZK (DOCK)
1WBR (DOCK)
1WIO (DOCK)
1WIP (DOCK)
1WIQ (DOCK)
2B4C (DOCK)
2JKR (DOCK)
2JKT (DOCK)
2KLU (DOCK)
2NXY (DOCK)
2NXZ (DOCK)
2NY0 (DOCK)
2NY1 (DOCK)
2NY2 (DOCK)
2NY3 (DOCK)
2NY4 (DOCK)
2NY5 (DOCK)
2NY6 (DOCK)
2QAD (DOCK)
3B71 (DOCK)
3CD4 (DOCK)
3JWD (DOCK)
3JWO (DOCK)
3LQA (DOCK)
3O2D (DOCK)
3S4S (DOCK)
3S5L (DOCK)
CD4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4 0 0 0
Binding ≤ 1μM 0 0 0 0
Functional ≤ 10μM 0 0 0 0

Reactome Network (9)

Reactome ID Description Species
REACT_115574 Alpha-defensins Homo sapiens
REACT_6903 Binding and entry of HIV virion Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_12623 Generation of second messenger molecules Homo sapiens
REACT_11166 Nef Mediated CD4 Down-regulation Homo sapiens
REACT_19324 PD-1 signaling Homo sapiens
REACT_12582 Phosphorylation of CD3 and TCR zeta chains Homo sapiens
REACT_12596 Translocation of ZAP-70 to Immunological synapse Homo sapiens
REACT_9031 Vpu mediated degradation of CD4 Homo sapiens
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CD11A_HUMAN Q9UQ88 CHEMBL5416 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 7 6 2 2
CD11B_HUMAN P21127 CHEMBL5808 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 7 6 2 2
CD22_HUMAN P20273 CHEMBL3218 CD22, Human 0 0 0 0
CD38_HUMAN P28907 CHEMBL4660 Lymphocyte Differentiation Antigen CD38, Human 3 3 3 0
CD5R1_HUMAN Q15078 CHEMBL2783 Cyclin-dependent Kinase 5 Regulatory Subunit 1, Human 4 2 0 1
CDC42_HUMAN P60953 CHEMBL6088 Cell Division Control Protein 42 Homolog, Human 10 0 1 0
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4 0 0 0
CDC7_HUMAN O00311 CHEMBL5443 Cell Division Cycle 7-related Protein Kinase, Human 223 5 0 1
CDD_HUMAN P32320 CHEMBL4502 Cytidine Deaminase, Human 24 3 4 1
CDK14_HUMAN O94921 CHEMBL6162 Serine/threonine-protein Kinase PFTAIRE-1, Human 7 6 4 4
CDK15_HUMAN Q96Q40 CHEMBL5856 Serine/threonine-protein Kinase PFTAIRE-2, Human 1 1 1 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 19 16 6 12
CDK17_HUMAN Q00537 CHEMBL5790 Serine/threonine-protein Kinase PCTAIRE-2, Human 10 7 4 7
CDK18_HUMAN Q07002 CHEMBL5316 Serine/threonine-protein Kinase PCTAIRE-3, Human 8 5 3 5
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 11 9 6 6
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1,178 87 26 64
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 2,142 81 22 100
CDK3_HUMAN Q00526 CHEMBL4442 Cyclin-dependent Kinase 3, Human 8 4 2 4
CDK4_HUMAN P11802 CHEMBL331 Cyclin-dependent Kinase 4, Human 628 19 4 32
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent Kinase 5, Human 125 22 7 17
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 18 7 5 5
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 63 17 6 13
CDK8_HUMAN P49336 CHEMBL5719 Cell Division Protein Kinase 8, Human 8 7 5 5
CDK9_HUMAN P50750 CHEMBL3116 Cyclin-dependent Kinase 9, Human 101 11 6 13
CDKA1_HUMAN O14519 CHEMBL5578 Cyclin-dependent Kinase 2-associated Protein 1, Human 18 0 0 0
CDKL1_HUMAN Q00532 CHEMBL5789 Cyclin-dependent Kinase-like 1, Human 1 0 0 0
CDKL2_HUMAN Q92772 CHEMBL5728 Cyclin-dependent Kinase-like 2, Human 3 3 3 3
CDKL3_HUMAN Q8IVW4 CHEMBL1163117 Cyclin-dependent Kinase-like 3, Human 1 1 1 1
CDKL5_HUMAN O76039 CHEMBL1163112 Cyclin-dependent Kinase-like 5, Human 0 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Q993A8_9HIV1 Q993A8 CHEMBL3022 Envelope Polyprotein GP120, 9hiv1 4