| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 18 | 7 | 0 | 0 |
| Binding ≤ 1μM | 7 | 1 | 0 | 0 |
| Functional ≤ 10μM | 5 | 1 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_196588 | Constitutive PI3K/AKT Signaling in Cancer | Mus musculus |
| REACT_203917 | EGFR downregulation | Mus musculus |
| REACT_236516 | EGFR interacts with phospholipase C-gamma | Mus musculus |
| REACT_198350 | EGFR Transactivation by Gastrin | Mus musculus |
| REACT_206286 | GAB1 signalosome | Mus musculus |
| REACT_245103 | GRB2 events in EGFR signaling | Mus musculus |
| REACT_188528 | GRB2 events in ERBB2 signaling | Mus musculus |
| REACT_215348 | PI3K events in ERBB2 signaling | Mus musculus |
| REACT_226341 | PIP3 activates AKT signaling | Mus musculus |
| REACT_188190 | PLCG1 events in ERBB2 signaling | Mus musculus |
| REACT_260286 | SHC1 events in EGFR signaling | Mus musculus |
| REACT_188574 | SHC1 events in ERBB2 signaling | Mus musculus |
| REACT_215461 | Signal transduction by L1 | Mus musculus |
| REACT_199123 | Signaling by constitutively active EGFR | Mus musculus |
| REACT_242976 | Signaling by EGFR | Mus musculus |
| REACT_188191 | Signaling by ERBB2 | Mus musculus |
| REACT_188579 | Signaling by ERBB4 | Mus musculus |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| PGFRA_MOUSE | P26618 | CHEMBL3466 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 4 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| PGFRA_MOUSE | P26618 | CHEMBL3466 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 4 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| EGFR_HUMAN | P00533 | CHEMBL203 | Epidermal Growth Factor Receptor ErbB1, Human | 2,620 | 184 | 29 | 40 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| EGFR-1-E | Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic | 1,348 | 68 | 17 | 26 |
| EGFR-2-E | Epidermal Growth Factor Receptor ErbB1 (cluster #2 Of 4), Eukaryotic | 272 | 64 | 5 | 4 |
| EGFR-3-E | Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic | 1,016 | 59 | 8 | 11 |
| EGFR-4-E | Epidermal Growth Factor Receptor ErbB1 (cluster #4 Of 4), Eukaryotic | 5 | 0 | 0 | 0 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| TBB2B_BOVIN | Q6B856 | CHEMBL3394 | Tubulin Beta Chain, Bovin | 6 |
| EGFR_HUMAN | P00533 | CHEMBL203 | Epidermal Growth Factor Receptor ErbB1, Human | 4 |
| PGFRA_MOUSE | P26618 | CHEMBL3466 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 4 |
| PGFRB_MOUSE | P05622 | CHEMBL2749 | Platelet-derived Growth Factor Receptor Beta, Mouse | 4 |
| Z80037 | Z80037 | CHEMBL614065 | Balb/MK | 4 |
| Z100492 | Z100492 | CHEMBL613878 | MCF10 (Normal Breast Epithelial Cells) | 1 |
| Z50425 | Z50425 | CHEMBL364 | Plasmodium Falciparum | 1 |
| Z80224 | Z80224 | CHEMBL387 | MCF7 (Breast Carcinoma Cells) | 1 |
| Z80530 | Z80530 | CHEMBL614946 | Swiss-3T3 (Fibroblast Cells) | 1 |
