UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: Pyridine-2,4-dicarboxylic acid Pyridine-2,4-dicarboxylic acid

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
EGLN1-1-E Egl Nine Homolog 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 7000 0.60 Binding ≤ 10μM
EGLN2-1-E Hypoxia-inducible Factor Prolyl Hydroxylase 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 7000 0.60 Binding ≤ 10μM
EGLN3-1-E Egl Nine Homolog 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 7000 0.60 Binding ≤ 10μM
KDM4A-2-E Lysine-specific Demethylase 4A (cluster #2 Of 2), Eukaryotic Eukaryotes 700 0.72 Binding ≤ 10μM
KDM4C-2-E Lysine-specific Demethylase 4C (cluster #2 Of 2), Eukaryotic Eukaryotes 9400 0.59 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.59 3.86 -104.44 0 5 -2 93 165.104 2 ↓
Hi High (pH 8-9.5) 0.23 6.89 -24.83 2 12 0 133 482.925 8 ↓
Lo Low (pH 4.5-6) 0.59 4.26 -63.76 1 5 -1 94 166.112 2 ↓

Analogs

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Popular Name: N-Oxalylglycine N-Oxalylglycine

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
EGLN1-2-E Egl Nine Homolog 1 (cluster #2 Of 2), Eukaryotic Eukaryotes 8000 0.71 Binding ≤ 10μM
EGLN2-2-E Hypoxia-inducible Factor Prolyl Hydroxylase 1 (cluster #2 Of 2), Eukaryotic Eukaryotes 842 0.85 Binding ≤ 10μM
P4HA1-2-E Prolyl 4-hydroxylase Alpha-1 Subunit (cluster #2 Of 2), Eukaryotic Eukaryotes 540 0.88 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.00 -1.85 -95.16 1 6 -2 109 145.07 3 ↓

Parameters Provided:

annotation.name = EGLN2_HUMAN
anotation.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN note AS n ON ci.sub_id_fk=n.sub_id_fk INNER JOIN annotation AS a ON n.anno_id_fk=a.anno_id  WHERE c.free = 1 AND a.short_desc LIKE 'EGLN2\\_HUMAN' AND c.purchasable IN (1,2,4,5)    LIMIT 50

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