UCSF

Glycogen Synthase Kinase-3 Beta, Mouse (1 Compounds)

Swissprot:
GSK3B_MOUSE
Stitch:
GSK3B_MOUSE
UniProt:
Q9WV60
ChEMBL:
CHEMBL1075321
Reactome:
REACT_220918
REACT_230286
REACT_252458
REACT_218396
REACT_196588
REACT_244852
REACT_203336
REACT_216784
REACT_261276
REACT_222185
REACT_260752
REACT_234076
REACT_248000
REACT_258576
REACT_250714
PDB:
Gsk3b

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1 1 0 0
Binding ≤ 1μM 1 1 0 0

Reactome Network (15)

Reactome ID Description Species
REACT_220918 AKT phosphorylates targets in the cytosol Mus musculus
REACT_230286 APC truncation mutants have impaired AXIN binding Mus musculus
REACT_252458 AXIN missense mutants destabilize the destruction complex Mus musculus
REACT_218396 Beta-catenin phosphorylation cascade Mus musculus
REACT_196588 Constitutive PI3K/AKT Signaling in Cancer Mus musculus
REACT_244852 CRMPs in Sema3A signaling Mus musculus
REACT_203336 Degradation of beta-catenin by the destruction complex Mus musculus
REACT_216784 disassembly of the destruction complex and recruitment of AXIN to the membrane Mus musculus
REACT_261276 misspliced GSK3beta mutants stabilize beta-catenin Mus musculus
REACT_222185 Regulation of HSF1-mediated heat shock response Mus musculus
REACT_260752 S33 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_234076 S37 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_248000 S45 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_258576 T41 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_250714 truncations of AMER1 destabilize the destruction complex Mus musculus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1,367 166 28 48
GSK3B_RAT P18266 CHEMBL3669 Glycogen Synthase Kinase-3 Beta, Rat 6 0 0 0

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
GSK3B-1-E Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic 1,121 117 13 36
GSK3B-2-E Glycogen Synthase Kinase-3 Beta (cluster #2 Of 7), Eukaryotic 21 14 3 0
GSK3B-3-E Glycogen Synthase Kinase-3 Beta (cluster #3 Of 7), Eukaryotic 17 13 2 0
GSK3B-4-E Glycogen Synthase Kinase-3 Beta (cluster #4 Of 7), Eukaryotic 126 4 1 5
GSK3B-5-E Glycogen Synthase Kinase-3 Beta (cluster #5 Of 7), Eukaryotic 29 2 0 0
GSK3B-6-E Glycogen Synthase Kinase-3 Beta (cluster #6 Of 7), Eukaryotic 17 7 0 0
GSK3B-7-E Glycogen Synthase Kinase-3 Beta (cluster #7 Of 7), Eukaryotic 38 10 9 8
Uniprot Swissprot Chembl Description Number Shared
E2AK2_HUMAN P19525 CHEMBL5785 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1