UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: 2,5-Pyridinedicarboxylic acid 2,5-Pyridinedicarboxylic acid

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
P4HA1-1-E Prolyl 4-hydroxylase Alpha-1 Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 800 0.71 Binding ≤ 10μM
P4HTM-1-E Hypoxia-inducible Factor Prolyl 4-hydroxylase (cluster #1 Of 1), Eukaryotic Eukaryotes 5500 0.61 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.08 1.94 -97.16 0 5 -2 93 165.104 2 ↓

Analogs

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Popular Name: N-Oxalylglycine N-Oxalylglycine

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
EGLN1-2-E Egl Nine Homolog 1 (cluster #2 Of 2), Eukaryotic Eukaryotes 8000 0.71 Binding ≤ 10μM
EGLN2-2-E Hypoxia-inducible Factor Prolyl Hydroxylase 1 (cluster #2 Of 2), Eukaryotic Eukaryotes 842 0.85 Binding ≤ 10μM
P4HA1-2-E Prolyl 4-hydroxylase Alpha-1 Subunit (cluster #2 Of 2), Eukaryotic Eukaryotes 540 0.88 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -3.00 -1.85 -95.16 1 6 -2 109 145.07 3 ↓

Parameters Provided:

annotation.name = P4HA1_RAT
anotation.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN note AS n ON ci.sub_id_fk=n.sub_id_fk INNER JOIN annotation AS a ON n.anno_id_fk=a.anno_id  WHERE c.free = 1 AND a.short_desc LIKE 'P4HA1\\_RAT' AND c.purchasable IN (1,2,4,5)    LIMIT 50

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