UCSF

Replication Protein A 70 KDa DNA-binding Subunit, Human (2 Compounds)

Swissprot:
RFA1_HUMAN
Stitch:
RFA1_HUMAN
UniProt:
P27694
ChEMBL:
CHEMBL1764940
Reactome:
REACT_6769
REACT_1095
REACT_2141
REACT_311
REACT_257
REACT_200744
REACT_27271
REACT_228019
REACT_228145
REACT_408
REACT_2055
REACT_200780
REACT_70
REACT_7999
REACT_1993
REACT_378
PDB:
1EWI (DOCK)
1FGU (DOCK)
1JMC (DOCK)
1L1O (DOCK)
2B29 (DOCK)
2B3G (DOCK)
RPA1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 2 0 0
Binding ≤ 1μM 0 0 0 0

Reactome Network (16)

Reactome ID Description Species
REACT_6769 Activation of ATR in response to replication stress Homo sapiens
REACT_1095 Activation of the pre-replicative complex Homo sapiens
REACT_2141 Assembly of the RAD51-ssDNA nucleoprotein complex Homo sapiens
REACT_311 Dual incision reaction in GG-NER Homo sapiens
REACT_257 Formation of incision complex in GG-NER Homo sapiens
REACT_200744 HSF1 activation Homo sapiens
REACT_27271 Meiotic recombination Homo sapiens
REACT_228019 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Homo sapiens
REACT_228145 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Homo sapiens
REACT_408 Presynaptic phase of homologous DNA pairing and strand exchange Homo sapiens
REACT_2055 Processing of DNA double-strand break ends Homo sapiens
REACT_200780 Regulation of HSF1-mediated heat shock response Homo sapiens
REACT_70 Removal of the Flap Intermediate Homo sapiens
REACT_7999 Removal of the Flap Intermediate from the C-strand Homo sapiens
REACT_1993 Repair synthesis for gap-filling by DNA polymerase in TC-NER Homo sapiens
REACT_378 Repair synthesis of patch ~27-30 bases long by DNA polymerase Homo sapiens

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
P53_HUMAN P04637 CHEMBL4096 Cellular Tumor Antigen P53, Human 2