UCSF

Cellular Tumor Antigen P53, Human (15 Compounds)

Swissprot:
P53_HUMAN
Stitch:
P53_HUMAN
UniProt:
P04637
ChEMBL:
CHEMBL4096
Reactome:
REACT_1194
REACT_121
REACT_20549
REACT_169185
REACT_24970
REACT_169121
REACT_169325
REACT_169436
REACT_118568
REACT_309
REACT_346
PDB:
1A1U (DOCK)
1AIE (DOCK)
1C26 (DOCK)
1DT7 (DOCK)
1GZH (DOCK)
1H26 (DOCK)
1HS5 (DOCK)
1JSP (DOCK)
1KZY (DOCK)
1MA3 (DOCK)
1OLG (DOCK)
1OLH (DOCK)
1PES (DOCK)
1PET (DOCK)
1SAE (DOCK)
1SAF (DOCK)
1SAH (DOCK)
1SAJ (DOCK)
1SAK (DOCK)
1SAL (DOCK)
1TSR (DOCK)
1TUP (DOCK)
1UOL (DOCK)
1XQH (DOCK)
1YC5 (DOCK)
1YCQ (DOCK)
1YCR (DOCK)
1YCS (DOCK)
2AC0 (DOCK)
2ADY (DOCK)
2AHI (DOCK)
2ATA (DOCK)
2B3G (DOCK)
2BIM (DOCK)
2BIN (DOCK)
2BIO (DOCK)
2BIP (DOCK)
2BIQ (DOCK)
2F1X (DOCK)
2FEJ (DOCK)
2FOJ (DOCK)
2FOO (DOCK)
2GS0 (DOCK)
2H1L (DOCK)
2H2D (DOCK)
2H2F (DOCK)
2H4F (DOCK)
2H4H (DOCK)
2H4J (DOCK)
2H59 (DOCK)
2J0Z (DOCK)
2J10 (DOCK)
2J11 (DOCK)
2J1W (DOCK)
2J1X (DOCK)
2J1Y (DOCK)
2J1Z (DOCK)
2J20 (DOCK)
2J21 (DOCK)
2K8F (DOCK)
2L14 (DOCK)
2OCJ (DOCK)
2PCX (DOCK)
2QVQ (DOCK)
2QXA (DOCK)
2QXB (DOCK)
2QXC (DOCK)
2VUK (DOCK)
2WGX (DOCK)
2X0U (DOCK)
2X0V (DOCK)
2X0W (DOCK)
2XWR (DOCK)
2YBG (DOCK)
2Z5S (DOCK)
2Z5T (DOCK)
3D05 (DOCK)
3D06 (DOCK)
3D07 (DOCK)
3D08 (DOCK)
3D09 (DOCK)
3D0A (DOCK)
3DAB (DOCK)
3DAC (DOCK)
3IGK (DOCK)
3IGL (DOCK)
3KMD (DOCK)
3KZ8 (DOCK)
3LW1 (DOCK)
3OQ5 (DOCK)
3PDH (DOCK)
3Q01 (DOCK)
3Q05 (DOCK)
3Q06 (DOCK)
3SAK (DOCK)
3TG5 (DOCK)
3TS8 (DOCK)
TP53

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 15 3 0 0
Binding ≤ 1μM 5 1 0 0

Reactome Network (11)

Reactome ID Description Species
REACT_1194 Activation of NOXA and translocation to mitochondria Homo sapiens
REACT_121 Activation of PUMA and translocation to mitochondria Homo sapiens
REACT_20549 Autodegradation of the E3 ubiquitin ligase COP1 Homo sapiens
REACT_169185 DNA Damage/Telomere Stress Induced Senescence Homo sapiens
REACT_24970 Factors involved in megakaryocyte development and platelet production Homo sapiens
REACT_169121 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Homo sapiens
REACT_169325 Oncogene Induced Senescence Homo sapiens
REACT_169436 Oxidative Stress Induced Senescence Homo sapiens
REACT_118568 Pre-NOTCH Transcription and Translation Homo sapiens
REACT_309 Stabilization of p53 Homo sapiens
REACT_346 Transcriptional activation of cell cycle inhibitor p21 Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MDM2_HUMAN Q00987 CHEMBL5023 P53-binding Protein Mdm-2, Human 1

Oxidative Stress Induced Senescence

Uniprot Swissprot Chembl Description Number Shared
MDM2_HUMAN Q00987 CHEMBL5023 P53-binding Protein Mdm-2, Human 1

Stabilization of p53

Uniprot Swissprot Chembl Description Number Shared
MDM2_HUMAN Q00987 CHEMBL5023 P53-binding Protein Mdm-2, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
P2RX1_HUMAN P51575 CHEMBL2094 P2X Purinoceptor 1, Human 1 1 1 0
P2RX3_HUMAN P56373 CHEMBL2998 P2X Purinoceptor 3, Human 1 1 1 0
P2RX7_HUMAN Q99572 CHEMBL4805 P2X Purinoceptor 7, Human 60 9 0 0
P2RY1_HUMAN P47900 CHEMBL4315 Purinergic Receptor P2Y1, Human 180 10 2 1
P2RY6_HUMAN Q15077 CHEMBL4714 Pyrimidinergic Receptor P2Y6, Human 2 1 2 0
P2Y12_HUMAN Q9H244 CHEMBL2001 Purinergic Receptor P2Y12, Human 611 10 0 0
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3 2 0 0
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 13 9 1 1
P3C2G_HUMAN O75747 CHEMBL1163120 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Gamma, Human 1 0 0 0
P4HTM_HUMAN Q9NXG6 CHEMBL3047 Hypoxia-inducible Factor Prolyl 4-hydroxylase, Human 19 5 0 0
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 13 9 5 0
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 13 9 5 0
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 52 7 4 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 47 5 3 2
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 133 5 7 2
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 227 2 1 0
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 57 1 1 0
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 22 1 1 0
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 20 0 0 0
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59 1 1 1
PA2G6_HUMAN O60733 CHEMBL3213 Calcium-independent Phospholipase A2, Human 28 2 0 0
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 315 7 3 3
PA2GC_HUMAN Q5R387 CHEMBL2097 Phospholipase A2 Group IIC, Human 17 0 0 0
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 33 2 2 1
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 30 2 2 1
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 25 2 2 1
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 49 1 1 1
PACR_HUMAN P41586 CHEMBL5399 Pituitary Adenylate Cyclase-activating Polypeptide Type I Receptor, Human 15 0 0 0
PAFA_HUMAN Q13093 CHEMBL3514 LDL-associated Phospholipase A2, Human 217 1 1 2
PAI1_HUMAN P05121 CHEMBL3475 Plasminogen Activator Inhibitor-1, Human 144 1 2 2
PAK1_HUMAN Q13153 CHEMBL4600 Serine/threonine-protein Kinase PAK 1, Human 6 3 2 2
PAK2_HUMAN Q13177 CHEMBL4487 Serine/threonine-protein Kinase PAK 2, Human 2 2 1 1
PAK3_HUMAN O75914 CHEMBL2999 Serine/threonine-protein Kinase PAK 3, Human 8 8 2 2
PAK4_HUMAN O96013 CHEMBL4482 Serine/threonine-protein Kinase PAK 4, Human 11 7 2 5
PAK6_HUMAN Q9NQU5 CHEMBL4311 Serine/threonine-protein Kinase PAK6, Human 4 4 2 2
PAK7_HUMAN Q9P286 CHEMBL4524 Serine/threonine-protein Kinase PAK7, Human 5 5 2 2
PAOX_HUMAN Q6QHF9 CHEMBL2105 Polyamine Oxidase, Human 4 1 0 1
PAR1_HUMAN P25116 CHEMBL3974 Proteinase Activated Receptor 1, Human 338 8 1 1
PARG_HUMAN Q86W56 CHEMBL1795143 Poly(ADP-ribose) Glycohydrolase, Human 2 0 0 0
PARP1_HUMAN P09874 CHEMBL3105 Poly [ADP-ribose] Polymerase-1, Human 1,263 60 8 13
PARP2_HUMAN Q9UGN5 CHEMBL5366 Poly [ADP-ribose] Polymerase 2, Human 47 7 2 2
PARP3_HUMAN Q9Y6F1 CHEMBL5083 Poly [ADP-ribose] Polymerase 3, Human 8 3 0 3
PARP4_HUMAN Q9UKK3 CHEMBL6142 Poly [ADP-ribose] Polymerase 4, Human 5 1 0 0
PCFT_HUMAN Q96NT5 CHEMBL1795188 Proton-coupled Folate Transporter, Human 1 0 0 0
PCKGC_HUMAN P35558 CHEMBL2911 Phosphoenolpyruvate Carboxykinase Cytosolic, Human 47 1 0 1
PCKGM_HUMAN Q16822 CHEMBL3096 Phosphoenolpyruvate Carboxykinase Mitochondrial, Human 28 1 0 1
PCP_HUMAN P42785 CHEMBL2335 Lysosomal Pro-X Carboxypeptidase, Human 116 21 5 5
PCSK4_HUMAN Q6UW60 CHEMBL4861 Subtilisin/kexin Type 4, Human 0 0 0 0
PCSK5_HUMAN Q92824 CHEMBL2826 Subtilisin/kexin Type 5, Human 5 0 0 0
PCSK6_HUMAN P29122 CHEMBL2951 Subtilisin/kexin Type 6, Human 5 0 0 0
PCSK7_HUMAN Q16549 CHEMBL2232 Subtilisin/kexin Type 7, Human 8 1 1 1
PCSK9_HUMAN Q8NBP7 CHEMBL2929 Subtilisin/kexin Type 9, Human 0 0 0 0
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 354 12 3 4
PDCD4_HUMAN Q53EL6 CHEMBL1781868 Programmed Cell Death Protein 4, Human 8 0 0 0
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 224 22 5 7
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 55 4 4 4
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 180 22 8 8
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 181 21 8 8
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 198 21 8 8
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 32 5 2 3
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 672 29 26 35
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 648 28 26 35
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1,453 57 24 30
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1,476 81 25 32
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1,060 50 22 28
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1,432 71 24 30
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 1,222 69 13 7
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 80 5 5 5
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 40 5 5 5
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 38 6 5 5
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 33 5 5 5
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 164 3 2 2
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 19 2 2 2
PDE8A_HUMAN O60658 CHEMBL4640 Phosphodiesterase 8A, Human 6 1 1 1
PDE8B_HUMAN O95263 CHEMBL4408 Phosphodiesterase 8B, Human 49 1 1 1
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 21 2 2 2
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 134 4 3 4
PDK2_HUMAN Q15119 CHEMBL3861 Pyruvate Dehydrogenase Kinase Isoform 2, Human 110 2 2 1
PDK3_HUMAN Q15120 CHEMBL3893 Pyruvate Dehydrogenase Kinase Isoform 3, Human 110 2 2 1
PDK4_HUMAN Q16654 CHEMBL4141 Pyruvate Dehydrogenase Kinase Isoform 4, Human 110 2 2 1
PDPK1_HUMAN O15530 CHEMBL2534 3-phosphoinositide Dependent Protein Kinase-1, Human 130 8 2 6
PDYN_HUMAN P01213 CHEMBL2227 Proenkephalin B, Human 1 0 1 0
PE2R1_HUMAN P34995 CHEMBL1811 Prostanoid EP1 Receptor, Human 213 6 3 4
PE2R2_HUMAN P43116 CHEMBL1881 Prostanoid EP2 Receptor, Human 193 10 3 3
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 475 9 3 4
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 376 7 2 2
PEN2_HUMAN Q9NZ42 CHEMBL2374 Gamma-secretase Subunit PEN-2, Human 348 3 0 0
PEPA_HUMAN P00790 CHEMBL3295 Pepsin A, Human 80 1 1 1
PEPC_HUMAN P20142 CHEMBL2136 Pepsinogen C, Human 35 0 0 0
PEPD_HUMAN P12955 CHEMBL4185 Xaa-Pro Dipeptidase, Human 7 1 1 2
PERF_HUMAN P14222 CHEMBL5480 Perforin-1, Human 52 3 0 0
PERM_HUMAN P05164 CHEMBL2439 Myeloperoxidase, Human 30 9 2 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 90 8 3 3
PGDH_HUMAN P15428 CHEMBL1293255 15-hydroxyprostaglandin Dehydrogenase [NAD+], Human 39 2 0 0
PGES2_HUMAN Q9H7Z7 CHEMBL4411 Prostaglandin E Synthase 2, Human 30 2 0 0
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 410 47 19 27
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 796 66 25 38
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 969 95 65 44
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2,153 141 77 52
PGK1_HUMAN P00558 CHEMBL2886 Phosphoglycerate Kinase 1, Human 34 0 0 0
PGK2_HUMAN P07205 CHEMBL3245 Phosphoglycerate Kinase 2, Human 34 0 0 0
PGTB1_HUMAN P53609 CHEMBL4135 Geranylgeranyl Transferase Type I Beta Subunit, Human 538 5 4 5
PH4H_HUMAN P00439 CHEMBL3076 Phenylalanine-4-hydroxylase, Human 4 4 0 0
PHKG1_HUMAN Q16816 CHEMBL4004 Phosphorylase Kinase Gamma Subunit 1, Human 48 19 7 10
PHKG2_HUMAN P15735 CHEMBL2349 Phosphorylase Kinase Gamma Subunit 2, Human 46 17 7 10
PHLP2_HUMAN Q6ZVD8 CHEMBL1275209 PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, Human 16 13 0 0
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 165 10 7 7
PI42B_HUMAN P78356 CHEMBL5667 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 9 9 3 5
PI42C_HUMAN Q8TBX8 CHEMBL1770034 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Gamma, Human 4 0 0 0
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 13 9 5 0
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 96 14 5 4
PI51A_HUMAN Q99755 CHEMBL5969 Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha, Human 8 8 2 4
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 312 58 11 13
PIM2_HUMAN Q9P1W9 CHEMBL4523 Serine/threonine-protein Kinase PIM2, Human 149 23 3 5
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 42 12 6 7
PIN1_HUMAN Q13526 CHEMBL2288 Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1, Human 67 1 0 0
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 4 2 0 0
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1,234 42 4 9
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 290 24 3 8
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 374 25 4 10
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 596 31 3 9
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 99 3 0 0
PKD2_HUMAN Q13563 CHEMBL5465 Polycystin-2, Human 30 1 0 0
PKN1_HUMAN Q16512 CHEMBL3384 Protein Kinase N1, Human 10 10 5 7
PKN2_HUMAN Q16513 CHEMBL3032 Protein Kinase N2, Human 24 9 3 6
PKR1_HUMAN Q8TCW9 CHEMBL5649 Prokineticin Receptor 1, Human 3 0 0 0
PKR2_HUMAN Q8NFJ6 CHEMBL5548 Prokineticin Receptor 2, Human 1 0 0 0
PLAP_HUMAN Q9Y263 CHEMBL6114 Phospholipase A-2-activating Protein, Human 16 7 0 0
PLCB3_HUMAN Q01970 CHEMBL5449 Phospholipase C-beta-3, Human 9 5 5 1
PLCB_HUMAN O15120 CHEMBL4772 1-acylglycerol-3-phosphate O-acyltransferase Beta, Human 97 2 0 0
PLCG1_HUMAN P19174 CHEMBL3964 Phospholipase C-gamma-1, Human 2 1 1 0
PLCG2_HUMAN P16885 CHEMBL4100 Phospholipase C-gamma-2, Human 22 15 6 1
PLD1_HUMAN Q13393 CHEMBL2536 Phospholipase D1, Human 95 9 3 2
PLD2_HUMAN O14939 CHEMBL2734 Phospholipase D2, Human 90 7 3 2
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 372 14 4 11
PLK2_HUMAN Q9NYY3 CHEMBL5938 Serine/threonine-protein Kinase PLK2, Human 40 3 2 2
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 81 8 4 5
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 24 15 7 11
PLMN_HUMAN P00747 CHEMBL1801 Plasminogen, Human 600 6 4 25
PLTP_HUMAN P55058 CHEMBL5962 Phospholipid Transfer Protein, Human 0 0 0 0
PMM2_HUMAN O15305 CHEMBL1741162 Phosphomannomutase 2, Human 2 0 0 0
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 3 3 2 2
PNMT_HUMAN P11086 CHEMBL4617 Phenylethanolamine N-methyltransferase, Human 202 39 4 13
PNPH_HUMAN P00491 CHEMBL4338 Purine Nucleoside Phosphorylase, Human 262 5 2 3
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 8 3 1 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 18 4 1 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 23 9 1 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 24 10 2 1
PP2BA_HUMAN Q08209 CHEMBL4445 Serine/threonine Protein Phosphatase 2B Catalytic Subunit, Alpha Isoform, Human 0 0 0 0
PP2BB_HUMAN P16298 CHEMBL5278 Serine/threonine Protein Phosphatase PP2B-alpha Catalytic Subunit, Human 0 0 0 0
PP2BC_HUMAN P48454 CHEMBL2694 Serine/threonine Protein Phosphatase 2B Catalytic Subunit, Gamma Isoform, Human 0 0 0 0
PPAC_HUMAN P24666 CHEMBL4903 Low Molecular Weight Phosphotyrosine Protein Phosphatase, Human 21 2 0 0
PPAP_HUMAN P15309 CHEMBL2633 Prostatic Acid Phosphatase, Human 16 2 0 4
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 1,414 22 16 24
PPARD_HUMAN Q03181 CHEMBL3979 Peroxisome Proliferator-activated Receptor Delta, Human 656 13 6 12
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1,767 48 20 29
PPBN_HUMAN P10696 CHEMBL3402 Alkaline Phosphatase Placental-like, Human 6 2 0 0
PPBT_HUMAN P05186 CHEMBL5979 Alkaline Phosphatase, Tissue-nonspecific Isozyme, Human 49 23 0 0
PPCE_HUMAN P48147 CHEMBL3202 Prolyl Endopeptidase, Human 214 12 1 2
PPGB_HUMAN P10619 CHEMBL6115 Lysosomal Protective Protein, Human 2 2 1 2
PPIA_HUMAN P62937 CHEMBL1949 Cyclophilin A, Human 56 8 0 0
PPIB_HUMAN P23284 CHEMBL2075 Cyclophilin B, Human 0 0 0 0
PPID_HUMAN Q08752 CHEMBL1697657 Peptidyl-prolyl Cis-trans Isomerase D, Human 0 0 0 0
PPM1A_HUMAN P35813 CHEMBL2437 Protein Phosphatase 2C Alpha, Human 2 0 0 0
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 17 1 1 1
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 1,336 42 15 10
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 10 10 10 10
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 525 20 4 8
PRKX_HUMAN P51817 CHEMBL5818 Serine/threonine-protein Kinase PRKX, Human 5 2 1 1
PRLR_HUMAN P16471 CHEMBL5588 Prolactin Receptor, Human 0 0 0 0
PROC_HUMAN P04070 CHEMBL4444 Vitamin K-dependent Protein C, Human 30 0 0 1
PRP4_HUMAN O43172 CHEMBL1163119 U4/U6 Small Nuclear Ribonucleoprotein Prp4, Human 1 1 1 1
PRSS8_HUMAN Q16651 CHEMBL5610 Prostasin, Human 9 0 0 0
PSA_HUMAN P55786 CHEMBL2264 Puromycin-sensitive Aminopeptidase, Human 5 0 0 0
PSB1_HUMAN P20618 CHEMBL4208 Proteasome Component C5, Human 1 0 0 0
PSB2_HUMAN P49721 CHEMBL3492 Proteasome Macropain Subunit, Human 7 0 0 0
PSB5_HUMAN P28074 CHEMBL4662 Proteasome Macropain Subunit MB1, Human 45 0 0 0
PSB8_HUMAN P28062 CHEMBL5620 Proteasome Subunit Beta Type-8, Human 11 0 0 1
PSMG1_HUMAN O95456 CHEMBL1075122 Proteasome Assembly Chaperone 1, Human 1 0 0 0
PSMG2_HUMAN Q969U7 CHEMBL1075123 Proteasome Assembly Chaperone 2, Human 1 0 0 0
PSMG3_HUMAN Q9BT73 CHEMBL1075137 Proteasome Assembly Chaperone 3, Human 1 0 0 0
PSN1_HUMAN P49768 CHEMBL2473 Presenilin 1, Human 247 1 0 0
PSN2_HUMAN P49810 CHEMBL3708 Presenilin 2, Human 246 0 0 0
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 769 26 16 6
PTCA_HUMAN Q14761 CHEMBL4806 Protein Tyrosine Phosphatase Receptor Type C-associated Protein, Human 4 0 1 0
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 234 16 0 1
PTGIS_HUMAN Q16647 CHEMBL4428 Prostaglandin I2 Synthase, Human 64 0 0 0
PTH1R_HUMAN Q03431 CHEMBL1793 Parathyroid Hormone Receptor, Human 1 0 0 0
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 77 11 7 8
PTN11_HUMAN Q06124 CHEMBL3864 Protein-tyrosine Phosphatase 2C, Human 45 6 4 2
PTN12_HUMAN Q05209 CHEMBL3236 Protein-tyrosine Phosphatase G1, Human 2 0 0 0
PTN13_HUMAN Q12923 CHEMBL2976 Protein-tyrosine Phosphatase 1E, Human 5 1 0 0
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1,512 31 25 26
PTN22_HUMAN Q9Y2R2 CHEMBL2889 Hematopoietic Cell Protein-tyrosine Phosphatase 70Z-PEP, Human 60 10 0 0
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 430 8 4 7
PTN6_HUMAN P29350 CHEMBL3166 Protein-tyrosine Phosphatase 1C, Human 27 0 0 0
PTN7_HUMAN P35236 CHEMBL2219 Protein-tyrosine Phosphatase LC-PTP, Human 49 4 0 0
PTPA_HUMAN Q15257 CHEMBL2505 Protein Phosphatase 2A Regulatory Subunit B', Human 23 9 1 1
PTPRA_HUMAN P18433 CHEMBL3918 Receptor-type Tyrosine-protein Phosphatase Alpha, Human 68 5 2 3
PTPRB_HUMAN P23467 CHEMBL2706 Receptor-type Tyrosine-protein Phosphatase Beta, Human 41 2 0 2
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 136 11 3 0
PTPRF_HUMAN P10586 CHEMBL3521 Receptor-type Tyrosine-protein Phosphatase F (LAR), Human 68 0 2 0
PUR2_HUMAN P22102 CHEMBL3972 GAR Transformylase, Human 109 3 2 6
PUR9_HUMAN P31939 CHEMBL2518 AICAR Transformylase, Human 21 6 1 0
PURA2_HUMAN P30520 CHEMBL4875 Adenylosuccinate Synthetase 2, Human 3 1 0 1
PYGB_HUMAN P11216 CHEMBL3856 Brain Glycogen Phosphorylase, Human 12 0 0 8
PYGL_HUMAN P06737 CHEMBL2568 Liver Glycogen Phosphorylase, Human 587 10 1 19
PYGM_HUMAN P11217 CHEMBL3526 Muscle Glycogen Phosphorylase, Human 135 4 1 11
PYR1_HUMAN P27708 CHEMBL3093 Dihydroorotase, Human 8 0 0 0
PYRD_HUMAN Q02127 CHEMBL1966 Dihydroorotate Dehydrogenase, Human 223 7 2 13

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MDM2-1-E P53-binding Protein Mdm-2 (cluster #1 Of 1), Eukaryotic 178 3 0 0
P53-1-E Cellular Tumor Antigen P53 (cluster #1 Of 2), Eukaryotic 2 2 0 0
P53-2-E Cellular Tumor Antigen P53 (cluster #2 Of 2), Eukaryotic 13 1 0 0
Uniprot Swissprot Chembl Description Number Shared
Z104305 Z104305 CHEMBL1907611 Tumour Suppressor P53/oncoprotein Mdm2 12
RFA1_HUMAN P27694 CHEMBL1764940 Replication Protein A 70 KDa DNA-binding Subunit, Human 2
MDM2_HUMAN Q00987 CHEMBL5023 P53-binding Protein Mdm-2, Human 1