UCSF

Transforming Growth Factor Beta-1, Human (7 Compounds)

Swissprot:
TGFB1_HUMAN
Stitch:
TGFB1_HUMAN
UniProt:
P01137
ChEMBL:
CHEMBL1795178
Reactome:
REACT_120727
REACT_163906
REACT_6213
REACT_150331
REACT_318
REACT_169165
REACT_169103
REACT_163942
REACT_120850
REACT_120726
REACT_169263
REACT_169445
REACT_169440
REACT_169192
REACT_27161
PDB:
1KLA (DOCK)
1KLC (DOCK)
1KLD (DOCK)
3KFD (DOCK)
TGFB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 7 1 0 0
Binding ≤ 1μM 7 1 0 0

Reactome Network (15)

Reactome ID Description Species
REACT_120727 Downregulation of TGF-beta receptor signaling Homo sapiens
REACT_163906 ECM proteoglycans Homo sapiens
REACT_6213 Influenza Virus Induced Apoptosis Homo sapiens
REACT_150331 Molecules associated with elastic fibres Homo sapiens
REACT_318 Platelet degranulation Homo sapiens
REACT_169165 SMAD2/3 MH2 Domain Mutants in Cancer Homo sapiens
REACT_169103 SMAD2/3 Phosphorylation Motif Mutants in Cancer Homo sapiens
REACT_163942 Syndecan interactions Homo sapiens
REACT_120850 TGF-beta receptor signaling activates SMADs Homo sapiens
REACT_120726 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Homo sapiens
REACT_169263 TGFBR1 KD Mutants in Cancer Homo sapiens
REACT_169445 TGFBR1 LBD Mutants in Cancer Homo sapiens
REACT_169440 TGFBR2 Kinase Domain Mutants in Cancer Homo sapiens
REACT_169192 TGFBR2 MSI Frameshift Mutants in Cancer Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

SMAD2/3 MH2 Domain Mutants in Cancer

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

SMAD2/3 Phosphorylation Motif Mutants in Cancer

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

TGF-beta receptor signaling activates SMADs

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

TGFBR1 KD Mutants in Cancer

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

TGFBR1 LBD Mutants in Cancer

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

TGFBR2 Kinase Domain Mutants in Cancer

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1

Most Common Rings