ZINC 12

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.03	7.36	-51.43	1	5	-1	86	318.374	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.03	7.44	-129.36	0	5	-2	88	317.366	6	↓ MOL2 SDF SMILES Flexibase

14965006

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: DNC006718 DNC006718

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	350	0.43	Binding ≤ 10μM
Z80957-1-O	HMEC (Microvascular Endothelial Cells) (cluster #1 Of 2), Other	Other	400	0.43	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.55	6.74	-48.63	1	5	-1	86	304.347	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.55	6.9	-134.19	0	5	-2	88	303.339	4	↓ MOL2 SDF SMILES Flexibase

35930493

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: DNC006720 DNC006720

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Vendors

And 7 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9100	0.34	Binding ≤ 10μM
Z80957-1-O	HMEC (Microvascular Endothelial Cells) (cluster #1 Of 2), Other	Other	3000	0.37	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.21	6.36	-112.33	0	5	-2	88	388.626	4	↓ MOL2 SDF SMILES Flexibase

1909912

Analogs

Draw Identity 99% 90% 80% 70%

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Vendors

Ryan Scientific
- 048-04791
Ryan Scientific BB
- 093-62090

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	110	0.42	Binding ≤ 10μM
Z50587-4-O	Homo Sapiens (cluster #4 Of 9), Other	Other	100	0.43	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.62	3.3	-54.66	6	6	1	106	360.887	8	↓ MOL2 SDF SMILES Flexibase

19288411

Analogs

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Vendors

And 3 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3900	0.33	Binding ≤ 10μM
Z80957-1-O	HMEC (Microvascular Endothelial Cells) (cluster #1 Of 2), Other	Other	2000	0.35	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL

14964411

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: DNC006719 DNC006719

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Vendors

And 7 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.41	Binding ≤ 10μM
Z80164-1-O	HT-1080 (Fibrosarcoma Cells) (cluster #1 Of 6), Other	Other	7200	0.36	Functional ≤ 10μM
Z80957-1-O	HMEC (Microvascular Endothelial Cells) (cluster #1 Of 2), Other	Other	100	0.49	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.17	5.82	-51.6	1	5	-1	86	290.32	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.17	5.89	-128.71	0	5	-2	88	289.312	4	↓ MOL2 SDF SMILES Flexibase

3914617

Analogs

5195724
5195735
5195767
5195776

Draw Identity 99% 90% 80% 70%

Popular Name: TNP-470 TNP-470

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Vendors

Sigma Aldrich (Building Blocks)
- T1455|SIGMA

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1050	0.31	Binding ≤ 10μM
Z100729-1-O	AEC (Aortic Endothelial Cells) (cluster #1 Of 1), Other	Other	0	0.00	Functional ≤ 10μM
Z80852-1-O	A-431 (Epidermoid Carcinoma Cells) (cluster #1 Of 3), Other	Other	5300	0.27	Functional ≤ 10μM
Z81020-2-O	HepG2 (Hepatoblastoma Cells) (cluster #2 Of 8), Other	Other	860	0.31	Functional ≤ 10μM
Z81057-2-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #2 Of 4), Other	Other	500	0.33	Functional ≤ 10μM
Z81247-3-O	HeLa (Cervical Adenocarcinoma Cells) (cluster #3 Of 9), Other	Other	2020	0.30	Functional ≤ 10μM
Z81057-5-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #5 Of 5), Other	Other	1	0.47	ADME/T ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.72	-0.84	-18.21	1	7	0	89	401.887	7	↓ MOL2 SDF SMILES Flexibase

3925938

Analogs

5053046
5053047
5053048
5053049

Draw Identity 99% 90% 80% 70%

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Vendors

None

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AMPM2-1-E	Methionine Aminopeptidase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
Z80852-1-O	A-431 (Epidermoid Carcinoma Cells) (cluster #1 Of 3), Other	Other	7500	0.34	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.40	-2.06	-11.72	1	5	0	71	296.363	4	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

target.name = AMPM2-1-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'AMPM2-1-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

Permalink

//zinc12.docking.org/results/combination?target.name=AMPM2-1-E&target.type=B10&filter.purchasability=purchasable

Embed Link to Results

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<script type="text/javascript" src="//zinc12.docking.org/js/embed.js"></script>
<script type="text/javascript">
    window.zinc.embed('zinc-link', {
        "target.name": "AMPM2-1-E",        
        "target.type": "B10"        

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