In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
March 6th, 2009 | 30 | Yes |
Popular Name: 1-[bis(4-methoxyphenyl)methyl]-4-phenyl-piperidin-4-ol 1-[bis(4-methoxyphenyl)methyl]-4…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.06 | 10.79 | -42.66 | 2 | 4 | 1 | 43 | 404.53 | 6 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
OPRK-1-E | Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic | Eukaryotes | 2878 | 0.26 | Binding ≤ 10μM |
OPRM-1-E | Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 843 | 0.28 | Binding ≤ 10μM |
OPRX-1-E | Nociceptin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 439 | 0.30 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
OPRM_HUMAN | P35372 | Mu Opioid Receptor, Human | 843 | 0.28 | Binding ≤ 1μM |
OPRX_HUMAN | P41146 | Nociceptin Receptor, Human | 439 | 0.30 | Binding ≤ 1μM |
OPRK_HUMAN | P41145 | Kappa Opioid Receptor, Human | 2878 | 0.26 | Binding ≤ 10μM |
OPRM_HUMAN | P35372 | Mu Opioid Receptor, Human | 843 | 0.28 | Binding ≤ 10μM |
OPRX_HUMAN | P41146 | Nociceptin Receptor, Human | 439 | 0.30 | Binding ≤ 10μM |
Description | Species |
---|---|
G alpha (i) signalling events | |
G-protein activation | |
Opioid Signalling | |
Peptide ligand-binding receptors |