Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.45	7.28	-106.75	7	6	2	91	492.708	14	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.45	6.87	-112.97	7	6	2	88	492.708	14	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.45	6.92	-52.31	6	6	1	90	491.7	14	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.45	8.65	-121.87	7	6	2	91	492.708	14	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	8529	0.20	Binding ≤ 10μM
OPRK-4-E	Kappa Opioid Receptor (cluster #4 Of 6), Eukaryotic	Eukaryotes	1450	0.23	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	37	0.29	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	37	0.29	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	8529	0.20	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	1450	0.23	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	37	0.29	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)