UCSF

Dihydrofolate Reductase, Mouse (277 Compounds)

Swissprot:
DYR_MOUSE
Stitch:
DYR_MOUSE
UniProt:
P00375
ChEMBL:
CHEMBL4564
Reactome:
REACT_206830
REACT_198608
REACT_220137
REACT_199047
PDB:
1U70 (DOCK)
2FZJ (DOCK)
3D80 (DOCK)
3D84 (DOCK)
3K45 (DOCK)
3K47 (DOCK)
Dhfr

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 277 46 11 13
Binding ≤ 1μM 267 46 11 13
Uniprot Swissprot Chembl Description Number Shared
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 6

G1/S-Specific Transcription

Uniprot Swissprot Chembl Description Number Shared
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 6

Metabolism of folate and pterines

Uniprot Swissprot Chembl Description Number Shared
FOLC_MOUSE P48760 CHEMBL2890 Folylpoly-gamma-glutamate Synthetase, Mouse 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 86 4 1 13
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 895 73 24 46
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 355 18 7 16
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 585 34 8 19
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48 3 1 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR1A_MOUSE Q61214 CHEMBL4750 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse 7 5 0 1

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 57
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 39
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 21
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 18
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 10
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 6
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 6
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 5
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 4
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 4
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 4
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 3
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 3
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 3
FOLC_MOUSE P48760 CHEMBL2890 Folylpoly-gamma-glutamate Synthetase, Mouse 3
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
PUR2_MOUSE Q64737 CHEMBL3690 GAR Transformylase, Mouse 2
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 2
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 2
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 2
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2
C3SWJ7_ECOLX C3SWJ7 CHEMBL6137 Thymidylate Synthase, Ecolx 1
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 1
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 1
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 1
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 1
E2QDN0_ECOLX E2QDN0 CHEMBL1795153 Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1