| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 3rd, 2005 | 14 | Yes |
Popular Name: Clofibric acid Clofibric acid
Find On: PubMed — Wikipedia — Google
CAS Numbers: 14613-30-0 , 39087-48-4 , 7/9/882 , 882-09-7 , 9/7/882 , [882-09-7]
4-Chlorophenoxy-iso-butyrcc Acid
2-(4-chlorophenoxy)-2-methylpropanoic acid
2-(4-Chlorophenoxy)-2-methylpropionic acid
2-(4-Chlorophenoxy)-2-methylpropionic acid, 99%
2-(4-Chlorophenoxy)isobutyric Acid
2-(4-Chlorophenoxy)isobutyric acid, 98%
2-(4-Chlorophenoxy)IsobutyricAcid
2-(p-Chlorophenoxy)-2-methylpropionic acid
4-Chlorophenoxy isobutyric acid
4-Chlorophenoxy-iso-butyrcc Acid
882-09-7; C13700; Clofibric acid
882-09-7; Clofibric acid; Prestwick_39
acide clofibrique; acido clofibrico; acidum clofibricum; clofibric acid
CHLOROPHENOXYMETHYLPROPANOICACI
INN); Magnesium Clofibrate (INN); Calcium Clofibrate (INN)
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.73 | 6.68 | -42.53 | 0 | 3 | -1 | 49 | 213.64 | 3 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| MP | 104 - 106 | Enamine Building Blocks |
| MP | 104...106 | Enamine Building Blocks |
| Melting_Point | 119-120? | Alfa-Aesar |
| Melting_Point | 119-120° | Alfa-Aesar |
| MP | 120 | TCI |
| Mp [°C] | 120 - 123 | Acros Organics |
| MP | 121-123° | Matrix Scientific |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 95% | Fluorochem |
| UniProt Database Links | ACO12_RAT | ChEBI |
| Therapy | antihyperlipoproteinemic | SMDC Iconix |
| Warnings | IRRITANT | Matrix Scientific |
| Target | Others | Selleck Chemicals |
| Indications | pesticide, herbicide | KeyOrganics Bioactives |
| Target | PPAR | Selleck Chemicals |
| S phrase | S24/25: Avoid contact with skin and eyes. | Acros Organics |
| Patent Database Links | US2007196350; US2007264334; WO2005011677; WO2007101005 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PPARA-1-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #1 Of 3), Eukaryotic | Eukaryotes | 42 | 0.74 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PPARA_MOUSE | P23204 | Peroxisome Proliferator-activated Receptor Alpha, Mouse | 42 | 0.74 | Binding ≤ 1μM |
| PPARA_MOUSE | P23204 | Peroxisome Proliferator-activated Receptor Alpha, Mouse | 42 | 0.74 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Circadian Clock | |
| Nuclear Receptor transcription pathway | |
| PPARA activates gene expression | |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp | |
| REV-ERBA represses gene expression | |
| RORA activates circadian gene expression | |
| Transcriptional activation of mitochondrial biogenesis | |
| Transcriptional regulation of white adipocyte differentiation | |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression |
No pre-computed analogs available. Try a structural similarity search.