| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 19th, 2008 | 31 | No |
Popular Name: DNC012846 DNC012846
Find On: PubMed — Wikipedia — Google
CAS Numbers: 92586-35-1 , [127753-52-0]
3'-Azido-3'-deoxythymidine 5'-triphosphate triethylammonium salt
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOD1-1-E | DNA Polymerase Delta Subunit 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2300 | 0.25 | Binding ≤ 10μM |
| DPOL-1-V | Human Herpesvirus 6 DNA Polymerase (cluster #1 Of 4), Viral | Viruses | 5800 | 0.24 | Binding ≤ 10μM |
| Q72547-1-V | Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #1 Of 6), Viral | Viruses | 91 | 0.32 | Binding ≤ 10μM |
| Z50602-1-O | Human Herpesvirus 1 (cluster #1 Of 2), Other | Other | 3300 | 0.25 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q72547_9HIV1 | Q72547 | Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 | 91 | 0.32 | Binding ≤ 1μM |
| DPOL_VZVD | P09252 | DNA Polymerase, Vzvd | 5800 | 0.24 | Binding ≤ 10μM |
| DPOL_HHV1K | P04292 | DNA Polymerase Catalytic Subunit, Hhv1k | 3300 | 0.25 | Binding ≤ 10μM |
| DPOD1_HUMAN | P28340 | DNA Polymerase Delta Subunit 1, Human | 2300 | 0.25 | Binding ≤ 10μM |
| Z50602 | Z50602 | Human Herpesvirus 1 | 3300 | 0.25 | Binding ≤ 10μM |
| DPOL_HHV11 | P04293 | Human Herpesvirus 1 DNA Polymerase, Hhv11 | 3300 | 0.25 | Binding ≤ 10μM |
| Q72547_9HIV1 | Q72547 | Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 | 2100 | 0.26 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cytosolic iron-sulfur cluster assembly | |
| Leading Strand Synthesis | |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of DNA patch containing abasic residue | |
| Removal of the Flap Intermediate | |
| Removal of the Flap Intermediate from the C-strand | |
| Repair synthesis for gap-filling by DNA polymerase in TC-NER | |
| Repair synthesis of patch ~27-30 bases long by DNA polymerase | |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | |
| Telomere C-strand (Lagging Strand) Synthesis |
