| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 26 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.04 | 10.2 | -40.45 | 1 | 5 | 1 | 52 | 365.482 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1-1-E | Metabotropic Glutamate Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 407 | 0.34 | Binding ≤ 10μM |
| GRM1-1-E | Metabotropic Glutamate Receptor 1 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 407 | 0.34 | Functional ≤ 10μM |
| GRM5-1-E | Metabotropic Glutamate Receptor 5 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 3540 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 407 | 0.34 | Binding ≤ 1μM |
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 407 | 0.34 | Binding ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 407 | 0.34 | Functional ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 3540 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (q) signalling events |
