| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 24th, 2008 | 20 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.48 | 5.98 | -54.26 | 1 | 10 | -1 | 165 | 278.156 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1-2-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 150 | 0.48 | Binding ≤ 10μM |
| GRIK2-1-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 150 | 0.48 | Binding ≤ 10μM |
| GRIK3-1-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 150 | 0.48 | Binding ≤ 10μM |
| GRIK4-1-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 150 | 0.48 | Binding ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 150 | 0.48 | Binding ≤ 10μM |
| GRIK1-1-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 300 | 0.46 | Functional ≤ 10μM |
| GRIK2-1-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 300 | 0.46 | Functional ≤ 10μM |
| GRIK3-1-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 300 | 0.46 | Functional ≤ 10μM |
| GRIK4-1-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 300 | 0.46 | Functional ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 300 | 0.46 | Functional ≤ 10μM |
| Z104302-4-O | Glutamate NMDA Receptor (cluster #4 Of 7), Other | Other | 1800 | 0.40 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 3), Other | Other | 570 | 0.44 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 150 | 0.48 | Binding ≤ 1μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 150 | 0.48 | Binding ≤ 1μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 150 | 0.48 | Binding ≤ 1μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 150 | 0.48 | Binding ≤ 1μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 150 | 0.48 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 1800 | 0.40 | Binding ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 150 | 0.48 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 150 | 0.48 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 150 | 0.48 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 150 | 0.48 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 150 | 0.48 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 570 | 0.44 | Functional ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 300 | 0.46 | Functional ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 300 | 0.46 | Functional ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 300 | 0.46 | Functional ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 300 | 0.46 | Functional ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 300 | 0.46 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors |
