Physical Representations
|
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
|
Ref
Reference (pH 7)
|
3.53 |
2.27 |
-8.06 |
1 |
5 |
0 |
56 |
317.295 |
4 |
↓
|
Vendor Notes
| Note Type |
Comments |
Provided By |
| melting_point |
235 - 237 |
KeyOrganics |
Clustered Target Annotations
| Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
VGFR2-1-E |
Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
2900 |
0.34 |
Binding ≤ 10μM
|
ChEMBL Target Annotations
| Uniprot |
Swissprot |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
VGFR2_HUMAN |
P35968
|
Vascular Endothelial Growth Factor Receptor 2, Human |
2900 |
0.34 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
| Description |
Species |
|
EPHA-mediated growth cone collapse |
|
|
Integrin cell surface interactions |
|
|
Neurophilin interactions with VEGF and VEGFR |
|
|
VEGF binds to VEGFR leading to receptor dimerization |
|
|
VEGFA-VEGFR2 Pathway |
|
|
VEGFR2 mediated cell proliferation |
|
No pre-computed analogs available. Try a structural similarity search.
