| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 6th, 2008 | 41 | No |
Popular Name: LS-28521 LS-28521
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.61 | 11.95 | -20.98 | 1 | 5 | 0 | 62 | 587.442 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KCNH2-1-E | HERG (cluster #1 Of 5), Eukaryotic | Eukaryotes | 6000 | 0.18 | Binding ≤ 10μM |
| KCND3-1-E | Voltage-gated Potassium Channel Subunit Kv4.3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.28 | Functional ≤ 10μM |
| KCNH2-1-E | HERG (cluster #1 Of 2), Eukaryotic | Eukaryotes | 6000 | 0.18 | Functional ≤ 10μM |
| KCNQ1-1-E | Voltage-gated Potassium Channel Subunit Kv7.1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.28 | Functional ≤ 10μM |
| Z50512-1-O | Cavia Porcellus (cluster #1 Of 7), Other | Other | 6000 | 0.18 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KCNH2_HUMAN | Q12809 | HERG, Human | 6000 | 0.18 | Binding ≤ 10μM |
| Z50512 | Z50512 | Cavia Porcellus | 6 | 0.28 | Functional ≤ 10μM |
| KCNH2_HUMAN | Q12809 | HERG, Human | 6000 | 0.18 | Functional ≤ 10μM |
| KCND3_HUMAN | Q9UK17 | Voltage-gated Potassium Channel Subunit Kv4.3, Human | 6 | 0.28 | Functional ≤ 10μM |
| KCNQ1_CAVPO | O70344 | Voltage-gated Potassium Channel Subunit Kv7.1, Guinea Pig | 6 | 0.28 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Voltage gated Potassium channels |
