| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2005 | 26 | Yes |
Popular Name: SB-242235 SB-242235
Find On: PubMed — Wikipedia — Google
CAS Numbers: 193746-75-7 , [193746-75-7]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.66 | 6.78 | -63.27 | 2 | 6 | 1 | 69 | 354.409 | 4 | ↓ |
| Mid Mid (pH 6-8) | 1.66 | 7.23 | -119.41 | 3 | 6 | 2 | 71 | 355.417 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HSPB1-1-E | Heat Shock Protein Beta-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 160 | 0.37 | Binding ≤ 10μM |
| KPCA-5-E | Protein Kinase C Alpha (cluster #5 Of 6), Eukaryotic | Eukaryotes | 83 | 0.38 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 17 | 0.42 | Binding ≤ 10μM |
| MK14-1-E | MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic | Eukaryotes | 40 | 0.40 | Binding ≤ 10μM |
| Z100081-1-O | PBMC (Peripheral Blood Mononuclear Cells) (cluster #1 Of 4), Other | Other | 170 | 0.36 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HSPB1_HUMAN | P04792 | Heat Shock Protein Beta-1, Human | 160 | 0.37 | Binding ≤ 1μM |
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 130 | 0.37 | Binding ≤ 1μM |
| KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 83 | 0.38 | Binding ≤ 1μM |
| KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 17 | 0.42 | Binding ≤ 1μM |
| HSPB1_HUMAN | P04792 | Heat Shock Protein Beta-1, Human | 160 | 0.37 | Binding ≤ 10μM |
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 130 | 0.37 | Binding ≤ 10μM |
| KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 83 | 0.38 | Binding ≤ 10μM |
| KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 17 | 0.42 | Binding ≤ 10μM |
| Z100081 | Z100081 | PBMC (Peripheral Blood Mononuclear Cells) | 170 | 0.36 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Acetylcholine regulates insulin secretion | |
| activated TAK1 mediates p38 MAPK activation | |
| Activation of NF-kappaB in B cells | |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | |
| Activation of the AP-1 family of transcription factors | |
| ADP signalling through P2Y purinoceptor 1 | |
| AUF1 (hnRNP D0) destabilizes mRNA | |
| Ca2+ pathway | |
| Calmodulin induced events | |
| CDO in myogenesis | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| DSCAM interactions | |
| EGFR Transactivation by Gastrin | |
| ERK/MAPK targets | |
| G alpha (z) signalling events | |
| HuR stabilizes mRNA | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| KSRP destabilizes mRNA | |
| NOD1/2 Signaling Pathway | |
| Oxidative Stress Induced Senescence | |
| p38MAPK events | |
| Platelet sensitization by LDL | |
| Regulation of KIT signaling | |
| Response to elevated platelet cytosolic Ca2+ | |
| Signaling by SCF-KIT | |
| Syndecan interactions | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
