| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 6th, 2004 | 18 | Yes |
Popular Name: Gemfibrozil Gemfibrozil
Find On: PubMed — Wikipedia — Google
CAS Numbers: , 25812-30-0 , [25812-30-0]
2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
2,2-Dimethyl-5-(2,5-zlyloxy)valeric acid
25812-30-0; C07020; Gemfibrozil
25812-30-0; CPD000058393; GEMFIBROZIL; SAM002564211
25812-30-0; D00334; Gemfibrozil (JAN/USP/INN); Lopid (TN)
25812-30-0; Gemfibrozil; Prestwick_637
5-(2,5-Dimethyl-phenoxy)-2,2-dimethyl-pentanoic acid
5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
Alphapharm Brand of Gemfibrozil
Biochemie Brand of Gemfibrozil
Cantabria Brand of Gemfibrozil
Chem mart Brand of Gemfibrozil
CPD000058393; GEMFIBROZIL; SAM002564211
DIMETHYLPHENOXYDIMETHYLPENTANOICACI
Farmasierra Brand of Gemfibrozil
Gemcor, Lopid, Jezil, Gen-Fibro
Gemcor, Lopid, Jezil, Gen-Fibro, Gemfibrozil
GEMFIBROZIL (SEE ALSO PEROXISOME PROJECT (GEMFIBROZIL))
Gemfibrozilo; gemfibrozil; gemfibrozilum
Healthsense Brand of Gemfibrozil
Novopharm Brand of Gemfibrozil
Parke Davis Brand of Gemfibrozil
pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
PEROXISOME PROJECT (GEMFIBROZIL) (SEE ALSO GEMFIBROZIL)
Pharmascience Brand of Gemfibrozil
Terry White Chemists Brand of Gemfibrozil
Terry White Chemists Gemfibrozil
United Drug Brand of Gemfibrozil
Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
Warner Lambert Brand of Gemfibrozil
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.77 | 9.33 | -46.38 | 0 | 3 | -1 | 49 | 249.33 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| BP | 159 / 0.02 | TCI |
| ALOGPS_SOLUBILITY | 2.78e-02 g/l | DrugBank-approved |
| MP | 61 | TCI |
| biological_use | Antihyperlipidaemic drug | IBScreen Bioactives |
| Therapy | antihyperlipoproteinemic | SMDC Iconix |
| Patent Database Links | EP1258253; EP1520590; EP1522310; EP1553091; EP1559419; EP1559710; EP1629835; EP1634605; EP1652913; EP1714648; EP1746099; EP1767223; EP1785144; EP1832576; EP1864680; EP1889847; EP1894567; EP1911462; EP1939188; EP1958636; EP1972336; EP1997489; US2002082257 | ChEBI |
| Indications | hyperlipidemia | KeyOrganics Bioactives |
| mechanism | Increases activity of Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) | IBScreen Bioactives |
| Warnings | IRRITANT | Matrix Scientific |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : G-1482; NCC_SUPPLIER_SAMPLE_COMMENTS : WHITE POWDER | NIH Clinical Collection via PubChem |
| Target | Others | Selleck Chemicals |
| Target | PPAR | Selleck Chemicals |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: G-1482; SUPPLIER_COMMENTS: WHITE POWDER | NIH Clinical Collection via PubChem |
| Indications | type IV & V hyperlipidemia | KeyOrganics Bioactives |
| Purity | USP25 | APIChem |
| UniProt Database Links | Y560_MYCTU | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FABPL-3-E | Fatty Acid-binding Protein, Liver (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1860 | 0.45 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FABPL_RAT | P02692 | Fatty Acid-binding Protein, Liver, Rat | 1860 | 0.45 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| PPARA activates gene expression | |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp |
