Note Type	Comments	Provided By
biological_use	Antineoplastic agent	ZereneX Building Blocks
ALOGPS_SOLUBILITY	8.91e-03 g/l	DrugBank-approved
Purity	95+%	Matrix Scientific
Purity	97%	Fluorochem
Purity	>99%	Fluorochem
Indications	antineoplastic	KeyOrganics Bioactives
biological_use	Antineoplastic agent	IBScreen Bioactives IBScreen Bioactives
Target	EGFR	Selleck Chemicals
mechanism	Inhibitor of epidermal growth factor receptor (EGFr) tyrosine kinase	ZereneX Building Blocks
Warnings	IRRITANT	Matrix Scientific
Reactome Database Links	REACT_115609	ChEBI
UniProt Database Links	STK10_BOVIN; STK10_HUMAN; STK10_MOUSE; STK10_RAT	ChEBI
biological_use	Used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer	IBScreen Bioactives

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	770	0.30	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
ADCK3-1-E	Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
ADCK4-1-E	Uncharacterized AarF Domain-containing Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.27	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
AURKA-3-E	Serine/threonine-protein Kinase Aurora-A (cluster #3 Of 3), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	600	0.30	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.29	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.27	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	51	0.35	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2400	0.27	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.29	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.29	Binding ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	870	0.29	Binding ≤ 10μM
ERBB4-1-E	Receptor Protein-tyrosine Kinase ErbB-4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1130	0.29	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	820	0.29	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	40	0.36	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
JAK3-2-E	Tyrosine-protein Kinase JAK3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	930	0.29	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.27	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7000	0.25	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.29	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
MK04-1-E	Mitogen-activated Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.27	Binding ≤ 10μM
MK09-1-E	C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	4000	0.26	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.30	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.28	Binding ≤ 10μM
MRCKG-1-E	Serine/threonine-protein Kinase MRCK Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	970	0.29	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.31	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	26	0.37	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	700	0.30	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	83	0.34	Binding ≤ 10μM
TBA1A-2-E	Tubulin Alpha-3 Chain (cluster #2 Of 3), Eukaryotic	Eukaryotes	230	0.32	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.29	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.30	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.30	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.26	Binding ≤ 10μM
ULK3-1-E	Serine/threonine-protein Kinase ULK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	630	0.30	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.27	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.27	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	19	0.37	Functional ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	299	0.31	Functional ≤ 10μM
Z103205-1-O	A431 (cluster #1 Of 4), Other	Other	96	0.34	Functional ≤ 10μM
Z103348-1-O	NCI-H2122 (cluster #1 Of 2), Other	Other	1000	0.29	Functional ≤ 10μM
Z80224-1-O	MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other	Other	20	0.37	Functional ≤ 10μM
Z80322-2-O	NCI-H358 (Lung Carcinama Cells) (cluster #2 Of 2), Other	Other	6000	0.25	Functional ≤ 10μM
Z80475-3-O	SK-BR-3 (Breast Adenocarcinoma) (cluster #3 Of 3), Other	Other	1560	0.28	Functional ≤ 10μM
Z80682-1-O	A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other	Other	270	0.32	Functional ≤ 10μM
Z81020-7-O	HepG2 (Hepatoblastoma Cells) (cluster #7 Of 8), Other	Other	80	0.34	Functional ≤ 10μM
Z81072-6-O	Jurkat (Acute Leukemic T-cells) (cluster #6 Of 10), Other	Other	2000	0.28	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
CTRO_HUMAN	O14578	Citron Rho-interacting Kinase, Human	680	0.30	Binding ≤ 1μM
EPHA6_HUMAN	Q9UF33	Ephrin Type-A Receptor 6, Human	440	0.31	Binding ≤ 1μM
EPHA8_HUMAN	P29322	Ephrin Type-A Receptor 8, Human	940	0.29	Binding ≤ 1μM
EGFR_HUMAN	P00533	Epidermal Growth Factor Receptor ErbB1, Human	15	0.38	Binding ≤ 1μM
DDR1_HUMAN	Q08345	Epithelial Discoidin Domain-containing Receptor 1, Human	790	0.29	Binding ≤ 1μM
LTK_HUMAN	P29376	Leukocyte Tyrosine Kinase Receptor, Human	890	0.29	Binding ≤ 1μM
MKNK1_HUMAN	Q9BUB5	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human	690	0.30	Binding ≤ 1μM
MYLK2_HUMAN	Q9H1R3	Myosin Light Chain Kinase 2, Human	970	0.29	Binding ≤ 1μM
TNK1_HUMAN	Q13470	Non-receptor Tyrosine-protein Kinase TNK1, Human	630	0.30	Binding ≤ 1μM
ERBB2_HUMAN	P04626	Receptor Protein-tyrosine Kinase ErbB-2, Human	120	0.33	Binding ≤ 1μM
STK10_HUMAN	O94804	Serine/threonine-protein Kinase 10, Human	19	0.37	Binding ≤ 1μM
SLK_HUMAN	Q9H2G2	Serine/threonine-protein Kinase 2, Human	110	0.34	Binding ≤ 1μM
AURKC_HUMAN	Q9UQB9	Serine/threonine-protein Kinase Aurora-C, Human	600	0.30	Binding ≤ 1μM
GAK_HUMAN	O14976	Serine/threonine-protein Kinase GAK, Human	3.1	0.41	Binding ≤ 1μM
RIPK2_HUMAN	O43353	Serine/threonine-protein Kinase RIPK2, Human	410	0.31	Binding ≤ 1μM
TNI3K_HUMAN	Q59H18	Serine/threonine-protein Kinase TNNI3K, Human	570	0.30	Binding ≤ 1μM
TBA1A_RAT	P68370	Tubulin Alpha-1 Chain, Rat	230	0.32	Binding ≤ 1μM
ABL1_HUMAN	P00519	Tyrosine-protein Kinase ABL, Human	160	0.33	Binding ≤ 1μM
ABL2_HUMAN	P42684	Tyrosine-protein Kinase ABL2, Human	200	0.32	Binding ≤ 1μM
BLK_HUMAN	P51451	Tyrosine-protein Kinase BLK, Human	190	0.32	Binding ≤ 1μM
JAK3_HUMAN	P52333	Tyrosine-protein Kinase JAK3, Human	930	0.29	Binding ≤ 1μM
LCK_HUMAN	P06239	Tyrosine-protein Kinase LCK, Human	250	0.32	Binding ≤ 1μM
LYN_HUMAN	P07948	Tyrosine-protein Kinase Lyn, Human	530	0.30	Binding ≤ 1μM
FLT3_HUMAN	P36888	Tyrosine-protein Kinase Receptor FLT3, Human	130	0.33	Binding ≤ 1μM
RET_HUMAN	P07949	Tyrosine-protein Kinase Receptor RET, Human	330	0.31	Binding ≤ 1μM
TIE1_HUMAN	P35590	Tyrosine-protein Kinase Receptor Tie-1, Human	850	0.29	Binding ≤ 1μM
SRC_HUMAN	P12931	Tyrosine-protein Kinase SRC, Human	700	0.30	Binding ≤ 1μM
ULK3_MOUSE	Q3U3Q1	ULK3 Kinase, Mouse	630	0.30	Binding ≤ 1μM
AAK1_HUMAN	Q2M2I8	Adaptor-associated Kinase, Human	1200	0.29	Binding ≤ 10μM
ALK_HUMAN	Q9UM73	ALK Tyrosine Kinase Receptor, Human	1200	0.29	Binding ≤ 10μM
BMP2K_HUMAN	Q9NSY1	BMP-2-inducible Protein Kinase, Human	1200	0.29	Binding ≤ 10μM
MK09_HUMAN	P45984	C-Jun N-terminal Kinase 2, Human	4000	0.26	Binding ≤ 10μM
KC1D_HUMAN	P48730	Casein Kinase I Delta, Human	3500	0.26	Binding ≤ 10μM
ADCK3_HUMAN	Q8NI60	Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human	1900	0.28	Binding ≤ 10μM
CTRO_HUMAN	O14578	Citron Rho-interacting Kinase, Human	680	0.30	Binding ≤ 10μM
EPHA3_HUMAN	P29320	Ephrin Type-A Receptor 3, Human	2400	0.27	Binding ≤ 10μM
EPHA6_HUMAN	Q9UF33	Ephrin Type-A Receptor 6, Human	440	0.31	Binding ≤ 10μM
EPHA7_HUMAN	Q15375	Ephrin Type-A Receptor 7, Human	1400	0.28	Binding ≤ 10μM
EPHA8_HUMAN	P29322	Ephrin Type-A Receptor 8, Human	940	0.29	Binding ≤ 10μM
EGFR_HUMAN	P00533	Epidermal Growth Factor Receptor ErbB1, Human	15	0.38	Binding ≤ 10μM
DDR1_HUMAN	Q08345	Epithelial Discoidin Domain-containing Receptor 1, Human	790	0.29	Binding ≤ 10μM
E2AK4_HUMAN	Q9P2K8	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human	4400	0.26	Binding ≤ 10μM
FGFR2_HUMAN	P21802	Fibroblast Growth Factor Receptor 2, Human	1900	0.28	Binding ≤ 10μM
MET_HUMAN	P08581	Hepatocyte Growth Factor Receptor, Human	3800	0.26	Binding ≤ 10μM
E2AK2_HUMAN	P19525	Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human	1300	0.28	Binding ≤ 10μM
LTK_HUMAN	P29376	Leukocyte Tyrosine Kinase Receptor, Human	890	0.29	Binding ≤ 10μM
MKNK2_HUMAN	Q9HBH9	MAP Kinase Signal-integrating Kinase 2, Human	1600	0.28	Binding ≤ 10μM
MKNK1_HUMAN	Q9BUB5	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human	690	0.30	Binding ≤ 10μM
MK04_HUMAN	P31152	Mitogen-activated Protein Kinase 4, Human	2500	0.27	Binding ≤ 10μM
MYLK2_HUMAN	Q9H1R3	Myosin Light Chain Kinase 2, Human	970	0.29	Binding ≤ 10μM
DMPK_HUMAN	Q09013	Myotonin-protein Kinase, Human	2900	0.27	Binding ≤ 10μM
TNK1_HUMAN	Q13470	Non-receptor Tyrosine-protein Kinase TNK1, Human	630	0.30	Binding ≤ 10μM
PGFRA_HUMAN	P16234	Platelet-derived Growth Factor Receptor Alpha, Human	1800	0.28	Binding ≤ 10μM
PGFRB_HUMAN	P09619	Platelet-derived Growth Factor Receptor Beta, Human	1400	0.28	Binding ≤ 10μM
ERBB2_HUMAN	P04626	Receptor Protein-tyrosine Kinase ErbB-2, Human	1520	0.28	Binding ≤ 10μM
ERBB4_HUMAN	Q15303	Receptor Protein-tyrosine Kinase ErbB-4, Human	1130	0.29	Binding ≤ 10μM
KS6A4_HUMAN	O75676	Ribosomal Protein S6 Kinase Alpha 4, Human	7000	0.25	Binding ≤ 10μM
STK10_HUMAN	O94804	Serine/threonine-protein Kinase 10, Human	19	0.37	Binding ≤ 10μM
SLK_HUMAN	Q9H2G2	Serine/threonine-protein Kinase 2, Human	110	0.34	Binding ≤ 10μM
AURKA_HUMAN	O14965	Serine/threonine-protein Kinase Aurora-A, Human	2200	0.27	Binding ≤ 10μM
AURKB_HUMAN	Q96GD4	Serine/threonine-protein Kinase Aurora-B, Human	1400	0.28	Binding ≤ 10μM
AURKC_HUMAN	Q9UQB9	Serine/threonine-protein Kinase Aurora-C, Human	600	0.30	Binding ≤ 10μM
GAK_HUMAN	O14976	Serine/threonine-protein Kinase GAK, Human	3.1	0.41	Binding ≤ 10μM
MRCKG_HUMAN	Q6DT37	Serine/threonine-protein Kinase MRCK Gamma, Human	3400	0.26	Binding ≤ 10μM
RIPK2_HUMAN	O43353	Serine/threonine-protein Kinase RIPK2, Human	410	0.31	Binding ≤ 10μM
TNI3K_HUMAN	Q59H18	Serine/threonine-protein Kinase TNNI3K, Human	570	0.30	Binding ≤ 10μM
KIT_HUMAN	P10721	Stem Cell Growth Factor Receptor, Human	1300	0.28	Binding ≤ 10μM
TBA1A_RAT	P68370	Tubulin Alpha-1 Chain, Rat	230	0.32	Binding ≤ 10μM
ABL1_HUMAN	P00519	Tyrosine-protein Kinase ABL, Human	160	0.33	Binding ≤ 10μM
ABL2_HUMAN	P42684	Tyrosine-protein Kinase ABL2, Human	200	0.32	Binding ≤ 10μM
BLK_HUMAN	P51451	Tyrosine-protein Kinase BLK, Human	190	0.32	Binding ≤ 10μM
FGR_HUMAN	P09769	Tyrosine-protein Kinase FGR, Human	1100	0.29	Binding ≤ 10μM
FRK_HUMAN	P42685	Tyrosine-protein Kinase FRK, Human	2000	0.28	Binding ≤ 10μM
HCK_HUMAN	P08631	Tyrosine-protein Kinase HCK, Human	1800	0.28	Binding ≤ 10μM
JAK3_HUMAN	P52333	Tyrosine-protein Kinase JAK3, Human	930	0.29	Binding ≤ 10μM
LCK_HUMAN	P06239	Tyrosine-protein Kinase LCK, Human	250	0.32	Binding ≤ 10μM
LYN_HUMAN	P07948	Tyrosine-protein Kinase Lyn, Human	530	0.30	Binding ≤ 10μM
FLT3_HUMAN	P36888	Tyrosine-protein Kinase Receptor FLT3, Human	130	0.33	Binding ≤ 10μM
RET_HUMAN	P07949	Tyrosine-protein Kinase Receptor RET, Human	1300	0.28	Binding ≤ 10μM
TIE1_HUMAN	P35590	Tyrosine-protein Kinase Receptor Tie-1, Human	850	0.29	Binding ≤ 10μM
TYRO3_HUMAN	Q06418	Tyrosine-protein Kinase Receptor TYRO3, Human	3900	0.26	Binding ≤ 10μM
SRC_HUMAN	P12931	Tyrosine-protein Kinase SRC, Human	1900	0.28	Binding ≤ 10μM
YES_HUMAN	P07947	Tyrosine-protein Kinase YES, Human	2200	0.27	Binding ≤ 10μM
ULK3_MOUSE	Q3U3Q1	ULK3 Kinase, Mouse	630	0.30	Binding ≤ 10μM
ADCK4_HUMAN	Q96D53	Uncharacterized AarF Domain-containing Protein Kinase 4, Human	2500	0.27	Binding ≤ 10μM
VGFR1_HUMAN	P17948	Vascular Endothelial Growth Factor Receptor 1, Human	4400	0.26	Binding ≤ 10μM
VGFR3_HUMAN	P35916	Vascular Endothelial Growth Factor Receptor 3, Human	2100	0.27	Binding ≤ 10μM
Z103205	Z103205	A431	96	0.34	Functional ≤ 10μM
Z80682	Z80682	A549 (Lung Carcinoma Cells)	270	0.32	Functional ≤ 10μM
EGFR_HUMAN	P00533	Epidermal Growth Factor Receptor ErbB1, Human	19.3	0.37	Functional ≤ 10μM
Z81020	Z81020	HepG2 (Hepatoblastoma Cells)	80	0.34	Functional ≤ 10μM
Z81072	Z81072	Jurkat (Acute Leukemic T-cells)	2000	0.28	Functional ≤ 10μM
Z80224	Z80224	MCF7 (Breast Carcinoma Cells)	10	0.39	Functional ≤ 10μM
Z103348	Z103348	NCI-H2122	1000	0.29	Functional ≤ 10μM
Z80322	Z80322	NCI-H358 (Lung Carcinama Cells)	6000	0.25	Functional ≤ 10μM
ERBB2_HUMAN	P04626	Receptor Protein-tyrosine Kinase ErbB-2, Human	299	0.31	Functional ≤ 10μM
Z80475	Z80475	SK-BR-3 (Breast Adenocarcinoma)	1560	0.28	Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description	Species
Signaling by constitutively active EGFR	Rattus norvegicus Sus scrofa Xenopus tropicalis Homo sapiens Bos taurus Taeniopygia guttata Caenorhabditis elegans Danio rerio Mus musculus Drosophila melanogaster Canis familiaris Gallus gallus

Reactome Annotations from Targets (via Uniprot)

Description	Species
Activated point mutants of FGFR2	Homo sapiens (FGFR2_HUMAN)
activated TAK1 mediates p38 MAPK activation	Homo sapiens (RIPK2_HUMAN)
Activation of the AP-1 family of transcription factors	Homo sapiens (MK09_HUMAN)
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge	Homo sapiens (LYN_HUMAN)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins	Homo sapiens (AURKA_HUMAN)
CD28 co-stimulation	Homo sapiens (LCK_HUMAN)
CD28 dependent PI3K/Akt signaling	Homo sapiens (LCK_HUMAN)
CD28 dependent Vav1 pathway	Homo sapiens (LCK_HUMAN)
CDO in myogenesis	Homo sapiens (ABL1_HUMAN)
Cell surface interactions at the vascular wall	Homo sapiens (LYN_HUMAN)
Circadian Clock	Homo sapiens (KC1D_HUMAN)
Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens (EGFR_HUMAN)
CTLA4 inhibitory signaling	Homo sapiens (LCK_HUMAN)
DAP12 signaling	Homo sapiens (LCK_HUMAN)
Downregulation of ERBB2:ERBB3 signaling	Homo sapiens (ERBB2_HUMAN)
Downstream signal transduction	Homo sapiens (PGFRB_HUMAN)
Downstream TCR signaling	Homo sapiens (RIPK2_HUMAN)
EGFR downregulation	Homo sapiens (EGFR_HUMAN)
EGFR interacts with phospholipase C-gamma	Homo sapiens (EGFR_HUMAN)
EGFR Transactivation by Gastrin	Homo sapiens (EGFR_HUMAN)
EPH-ephrin mediated repulsion of cells	Homo sapiens (YES_HUMAN)
EPH-Ephrin signaling	Homo sapiens (YES_HUMAN)
EPHA-mediated growth cone collapse	Homo sapiens (YES_HUMAN)
EPHB-mediated forward signaling	Homo sapiens (YES_HUMAN)
Factors involved in megakaryocyte development and platelet production	Homo sapiens (ABL1_HUMAN)
Fc epsilon receptor (FCERI) signaling	Homo sapiens (LYN_HUMAN)
FCERI mediated Ca+2 mobilization	Homo sapiens (LYN_HUMAN)
FCERI mediated MAPK activation	Homo sapiens (LYN_HUMAN)
FCERI mediated NF-kB activation	Homo sapiens (LYN_HUMAN)
FCGR activation	Homo sapiens (YES_HUMAN)
Formation of tubulin folding intermediates by CCT/TriC	Rattus norvegicus (TBA1A_RAT)
GAB1 signalosome	Homo sapiens (EGFR_HUMAN)
Gap junction assembly	Rattus norvegicus (TBA1A_RAT)
Generation of second messenger molecules	Homo sapiens (LCK_HUMAN)
Golgi Associated Vesicle Biogenesis	Homo sapiens (GAK_HUMAN)
GPVI-mediated activation cascade	Homo sapiens (LCK_HUMAN)
GRB2 events in EGFR signaling	Homo sapiens (EGFR_HUMAN)
GRB2 events in ERBB2 signaling	Homo sapiens (EGFR_HUMAN)
GRB7 events in ERBB2 signaling	Homo sapiens (ERBB2_HUMAN)
Growth hormone receptor signaling	Homo sapiens (LYN_HUMAN)
Inhibition of PKR	Homo sapiens (E2AK2_HUMAN)
Interleukin receptor SHC signaling	Homo sapiens (JAK3_HUMAN)
Interleukin-1 signaling	Homo sapiens (RIPK2_HUMAN)
Interleukin-2 signaling	Homo sapiens (LCK_HUMAN)
Interleukin-7 signaling	Homo sapiens (JAK3_HUMAN)
ISG15 antiviral mechanism	Homo sapiens (E2AK2_HUMAN)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human	Homo sapiens (RIPK2_HUMAN)
Kinesins	Rattus norvegicus (TBA1A_RAT)
Loss of Nlp from mitotic centrosomes	Rattus norvegicus (TBA1A_RAT) Homo sapiens (KC1D_HUMAN)
Loss of proteins required for interphase microtubule organizationÂ from the ce	Rattus norvegicus (TBA1A_RAT) Homo sapiens (KC1D_HUMAN)
MHC class II antigen presentation	Rattus norvegicus (TBA1A_RAT)
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Rattus norvegicus (TBA1A_RAT)
Mitotic Prometaphase	Rattus norvegicus (TBA1A_RAT) Homo sapiens (AURKB_HUMAN)
Nef and signal transduction	Homo sapiens (LCK_HUMAN)
Nef Mediated CD4 Down-regulation	Homo sapiens (LCK_HUMAN)
Neurophilin interactions with VEGF and VEGFR	Homo sapiens (VGFR1_HUMAN)
NOD1/2 Signaling Pathway	Homo sapiens (RIPK2_HUMAN)
Non-integrin membrane-ECM interactions	Homo sapiens (DDR1_HUMAN)
Oxidative Stress Induced Senescence	Homo sapiens (MK09_HUMAN)
p75NTR recruits signalling complexes	Homo sapiens (RIPK2_HUMAN)
PD-1 signaling	Homo sapiens (LCK_HUMAN)
PECAM1 interactions	Homo sapiens (LCK_HUMAN)
Phosphorylation of CD3 and TCR zeta chains	Homo sapiens (LCK_HUMAN)
PI3K events in ERBB2 signaling	Homo sapiens (EGFR_HUMAN)
PIP3 activates AKT signaling	Homo sapiens (EGFR_HUMAN)
Platelet Adhesion to exposed collagen	Homo sapiens (LYN_HUMAN)
Platelet sensitization by LDL	Homo sapiens (FGR_HUMAN)
PLCG1 events in ERBB2 signaling	Homo sapiens (EGFR_HUMAN)
Post-chaperonin tubulin folding pathway	Rattus norvegicus (TBA1A_RAT)
Prefoldin mediated transfer of substrate to CCT/TriC	Rattus norvegicus (TBA1A_RAT)
Recruitment of mitotic centrosome proteins and complexes	Homo sapiens (KC1D_HUMAN) Rattus norvegicus (TBA1A_RAT)
Recruitment of NuMA to mitotic centrosomes	Rattus norvegicus (TBA1A_RAT)
Recycling pathway of L1	Rattus norvegicus (TBA1A_RAT) Homo sapiens (KS6A4_HUMAN)
Regulation of actin dynamics for phagocytic cup formation	Homo sapiens (ABL1_HUMAN)
Regulation of KIT signaling	Homo sapiens (LCK_HUMAN)
Regulation of PLK1 Activity at G2/M Transition	Rattus norvegicus (TBA1A_RAT) Homo sapiens (AURKA_HUMAN)
Regulation of signaling by CBL	Homo sapiens (YES_HUMAN)
Resolution of Sister Chromatid Cohesion	Homo sapiens (AURKB_HUMAN) Rattus norvegicus (TBA1A_RAT)
Role of Abl in Robo-Slit signaling	Homo sapiens (ABL1_HUMAN)
Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens (LYN_HUMAN)
Sema4D induced cell migration and growth-cone collapse	Homo sapiens (ERBB2_HUMAN)
Sema4D mediated inhibition of cell attachment and migration	Homo sapiens (MET_HUMAN)
Separation of Sister Chromatids	Homo sapiens (AURKB_HUMAN) Rattus norvegicus (TBA1A_RAT)
SHC1 events in EGFR signaling	Homo sapiens (EGFR_HUMAN)
SHC1 events in ERBB2 signaling	Homo sapiens (EGFR_HUMAN)
Signal transduction by L1	Homo sapiens (EGFR_HUMAN)
Signaling by constitutively active EGFR	Homo sapiens (EGFR_HUMAN)
Signaling by EGFR	Homo sapiens (EGFR_HUMAN)
Signaling by ERBB2	Homo sapiens (EGFR_HUMAN)
Signaling by ERBB4	Homo sapiens (EGFR_HUMAN)
Signaling by FGFR mutants	Homo sapiens (FGFR2_HUMAN)
Signaling by FGFR2 amplification mutants	Homo sapiens (FGFR2_HUMAN)
Signaling by PDGF	Homo sapiens (PGFRB_HUMAN)
Signaling by SCF-KIT	Homo sapiens (LCK_HUMAN)
Spry regulation of FGF signaling	Homo sapiens (MKNK1_HUMAN)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Homo sapiens (RIPK2_HUMAN)
Translocation of GLUT4 to the plasma membrane	Rattus norvegicus (TBA1A_RAT)
Translocation of ZAP-70 to Immunological synapse	Homo sapiens (LCK_HUMAN)
VEGF binds to VEGFR leading to receptor dimerization	Homo sapiens (VGFR1_HUMAN)

Analogs ( Draw Identity 99% 90% 80% 70% )

Synonyms (87)
Vendors (42)
Annotations (22)
Representations (1)
Notes (13)
Targets (97)
Clustered (69)
Reactome (99)
Rings (0)
Analogs (8)