| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 30th, 2008 | 30 | No |
Popular Name: H-Arg-Gly-Asp-Cys-OH H-Arg-Gly-Asp-Cys-OH
Find On: PubMed — Wikipedia — Google
CAS Number: 109292-46-8
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -5.14 | -1.21 | -147.1 | 11 | 14 | 0 | 261 | 449.49 | 14 | ↓ |
| Ref Reference (pH 7) | -5.10 | -1.2 | -146.16 | 11 | 14 | 0 | 259 | 449.49 | 15 | ↓ |
| Hi High (pH 8-9.5) | -5.14 | -3.42 | -106.32 | 10 | 14 | -1 | 260 | 448.482 | 14 | ↓ |
| Hi High (pH 8-9.5) | -5.10 | -1.54 | -113.49 | 10 | 14 | -1 | 257 | 448.482 | 15 | ↓ |
| Lo Low (pH 4.5-6) | -5.14 | -4.25 | -122.77 | 12 | 14 | 1 | 258 | 450.498 | 14 | ↓ |
| Lo Low (pH 4.5-6) | -5.10 | -3.24 | -120.05 | 12 | 14 | 1 | 256 | 450.498 | 15 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ITA2B-1-E | Integrin Alpha-IIb (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.28 | Binding ≤ 10μM |
| ITB3-1-E | Integrin Beta-3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.28 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ITA2B_HUMAN | P08514 | Integrin Alpha-IIb, Human | 1000 | 0.28 | Binding ≤ 1μM |
| ITB3_HUMAN | P05106 | Integrin Beta-3, Human | 1000 | 0.28 | Binding ≤ 1μM |
| ITA2B_HUMAN | P08514 | Integrin Alpha-IIb, Human | 1000 | 0.28 | Binding ≤ 10μM |
| ITB3_HUMAN | P05106 | Integrin Beta-3, Human | 1000 | 0.28 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| ECM proteoglycans | |
| Elastic fibre formation | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| Integrin cell surface interactions | |
| Molecules associated with elastic fibres | |
| p130Cas linkage to MAPK signaling for integrins | |
| PECAM1 interactions | |
| Platelet degranulation | |
| Signal transduction by L1 | |
| Syndecan interactions | |
| VEGFA-VEGFR2 Pathway |
No pre-computed analogs available. Try a structural similarity search.