In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
August 26th, 2008 | 19 | No |
Popular Name: 136623-01-3; C13731; NS-102 136623-01-3; C13731; NS-102
Find On: PubMed — Wikipedia — Google
CAS Number: 136623-01-3
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.27 | 3.69 | -10.31 | 2 | 7 | 0 | 111 | 261.237 | 1 | ↓ |
Ref Reference (pH 7) | 2.94 | 3.63 | -114.38 | 0 | 7 | -2 | 112 | 259.221 | 2 | ↓ |
Hi High (pH 8-9.5) | 2.27 | 4.82 | -52.32 | 1 | 7 | -1 | 114 | 260.229 | 1 | ↓ |
Mid Mid (pH 6-8) | 2.94 | 4.69 | -42.67 | 1 | 7 | -1 | 114 | 260.229 | 2 | ↓ |
Lo Low (pH 4.5-6) | 2.94 | 3.72 | -14.44 | 2 | 7 | 0 | 111 | 261.237 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GRIA1-2-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 8100 | 0.38 | Binding ≤ 10μM |
GRIA2-1-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 8100 | 0.38 | Binding ≤ 10μM |
GRIA3-1-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 8100 | 0.38 | Binding ≤ 10μM |
GRIA4-1-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 8100 | 0.38 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 8100 | 0.38 | Binding ≤ 10μM |
GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 8100 | 0.38 | Binding ≤ 10μM |
GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 8100 | 0.38 | Binding ≤ 10μM |
GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 8100 | 0.38 | Binding ≤ 10μM |
Description | Species |
---|---|
Activation of AMPA receptors | |
Trafficking of GluR2-containing AMPA receptors | |
Unblocking of NMDA receptor, glutamate binding and activation |
No pre-computed analogs available. Try a structural similarity search.