UCSF

ZINC01639567

Substance Information

In ZINC since Heavy atoms Benign functionality
October 7th, 2004 10 Yes

Other Names:

(+)-(R)-Tranylcypromine

(+)-trans-2-Phenylcyclopropylamine

(+)-Tranylcypromine

(-)-Tranylcypromine

(1R)-2-phenylcyclopropan-1-amine

(1R,2R)-2-phenylcyclopropan-1-amine

(1R,2S)-2-phenylcyclopropan-1-amine

(1R,2S)-2-phenylcyclopropanamine

(1S)-2-phenylcyclopropan-1-amine

(1S,2R)-2-phenylcyclopropan-1-amine

(1S,2S)-2-phenylcyclopropan-1-amine

(2S)-2-phenylcyclopropan-1-amine

13492-01-8; D00826; Parnate (TN); Tranylcypromine sulfate (USP XXI)

155-09-9

155-09-9; C07155; Tranylcypromine

155-09-9; D08625; Parnate (TN); Tranylcypromine (INN)

1tnl

2-PCPA (hydrochloride)

2-Phenyl-1-aminocyclopropane, trans-

2-Phenyl-cyclopropylamine hydrochloride

2-phenylcyclopropan-1-amine

2-phenylcyclopropan-1-amine hydrochloride

2-phenylcyclopropanamine

2-Phenylcyclopropanamine hydrochloride

3-12-00-02797 (Beilstein Handbook Reference)

3721-26-4

3721-28-6

95-62-5

AC-15970

AC1L1ACF

AC1L1KJT

AC1L2E8J

AC1L9ASR

AC1L9B1D

AC1NWAQS

AC1O7GD6

AC1ODZ9B

AC1Q1HO4

AC1Q1HO9

AC1Q4UBQ

AC1Q53BI

Allphar Brand of Tranylcypromine Sulfate

AR-1E4939

BRD-A43974575-065-02-8

BRD-K88809146-003-02-1

BRN 2802413

BRN 3195803

BRN 3195803; C9H11N; CCRIS 3344; Cyclopropanamine, 2-phenyl-, trans-(+-)-; Cyclopropylamine, 2-phenyl-, trans-(+-)-; EINECS 205-841-9; HSDB 3404; LS-58824; NSC 80664; Parnitene; Racemic Tranylcypromine; SKF 385; SKF Trans-385; Tranilcipromina [INN-Spanish

BSPBio_002656

BSPBio_002898

C07155

C9H11N

CAS-1986-47-6

CBChromo1_000132

CCRIS 3344

CHEBI:231607

CHEBI:293460

CHEBI:527107

CHEBI:588391

CHEMBL1179

CHEMBL257990

CHEMBL313833

CHEMBL467794

CID19493

CID26070

CID441233

CID441360

CID5530

CID5702124

CID6604304

CID6971118

cis-2-phenylcyclopropylamine

Cyclopropanamine, 2-phenyl-, (1R,2S)-rel-

Cyclopropanamine, 2-phenyl-, (1R-trans)-

Cyclopropanamine, 2-phenyl-, (1R-trans)- (9CI)

Cyclopropanamine, 2-phenyl-, trans-

Cyclopropanamine, 2-phenyl-, trans-(+)-

Cyclopropanamine, 2-phenyl-, trans-(+-)-

Cyclopropanamine, 2-phenyl-, trans-(.+-.)-

Cyclopropanamine, 2-phenyl-, trans-(.+/-.)-

Cyclopropylamine, 2-phenyl-, (1S-trans)-

CYCLOPROPYLAMINE, 2-PHENYL-, trans-

Cyclopropylamine, 2-phenyl-, trans-(+-)-

Cyclopropylamine, 2-phenyl-, trans-(-)-

Cyclopropylamine, 2-phenyl-, trans-(.+-.)-

Cyclopropylamine, 2-phenyl-, trans-(.+/-.)-

Cyclopropylamine, trans-2-phenyl-

d-Tranylcypromine

D014191

D08625

DAP000081

DB00752

DivK1c_000588

Dl-Tranylcypromine

DNC009553

EINECS 205-841-9

esparma Brand of Tranylcypromine Sulfate

GJZ

GlaxoSmithKline Brand of Tranylcypromine Sulfate

Goldshield Brand of Tranylcypromine Sulfate

HMS2089B04

HSDB 3404

IDI1_000588

INN); Tranylcypromine Sulfate (FDA

Jatrosom

KBio1_000588

KBio2_001327

KBio2_002078

KBio2_003895

KBio2_004646

KBio2_006463

KBio2_007214

KBio3_001876

KBio3_002118

KBioGR_000821

KBioGR_001658

KBioSS_001327

KBioSS_002078

l-Tranylcypromine

Link Brand of Tranylcypromine Sulfate

LS-187134

LS-58822

LS-58823

LS-58824

MFCD00003575

MFCD04114536

MI

MLS001306494

MolPort-001-783-425

MolPort-001-791-393

MolPort-002-551-002

NCGC00015848-01

NCGC00015848-03

NCGC00016598-01

NCGC00162316-01

NCGC00178400-01

NCGC00178400-02

NCGC00179670-01

NINDS_000588

NSC 80664

NSC80664

Parnate

Parnitene

PDSP1_001095

PDSP1_001096

PDSP2_001079

PDSP2_001080

Prestwick0_000173

Prestwick1_000173

Prestwick2_000173

Racemic Tranylcypromine

SKF 385

SKF Trans-385

SmithKline Brand of Tranylcypromine Sulfate

SMR000039637

SPBio_000960

SPBio_001986

Spectrum2_000960

Spectrum3_001068

Spectrum3_001369

Spectrum4_000361

Spectrum4_001219

Spectrum5_001451

Spectrum5_001829

Spectrum_000847

Spectrum_001598

STOCK1S-62620

Sulfate, Tranylcypromine

Tranilcipromina

Tranilcipromina [INN-Spanish]

trans 2 Phenylcyclopropylamine

trans-(-)-2-Phenylcyclopropanamine

trans-2-Phenylcyclopropylamine

trans-DL-2-Phenylcyclopropylamine

Transamine

Tranylcypromine (BAN

Tranylcypromine (INN)

Tranylcypromine hydrochloride

Tranylcypromine Sulfate

Tranylcypromine [INN:BAN]

Tranylcyprominum

Tranylcyprominum [INN-Latin]

UNII-3E3V44J4Z9

USP)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.43 4.08 -38.81 3 1 1 28 134.202 1
Hi High (pH 8-9.5) 1.43 3.77 -2.86 2 1 0 26 133.194 1

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.49e+00 g/l DrugBank-approved
MP 155 - 157 Enamine Building Blocks
MP 155...157 Enamine Building Blocks
MP 156 - 158 Enamine Building Blocks
MP 162 - 169 Enamine Building Blocks
MP 162...169 Enamine Building Blocks
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Therapy MAO inhibitor; antidepressant SMDC MicroSource
PUBCHEM_PATENT_ID WO2000004021A1 IBM Patent Data

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AOFB-1-E Monoamine Oxidase B (cluster #1 Of 8), Eukaryotic Eukaryotes 33 1.05 Binding ≤ 10μM
5HT2C-1-E 5-hydroxytryptamine Receptor 2C (cluster #1 Of 2), Eukaryotic Eukaryotes 2697 0.78 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
AOFB_HUMAN P27338 Monoamine Oxidase B, Human 33 1.05 Binding ≤ 1μM
AOFB_HUMAN P27338 Monoamine Oxidase B, Human 33 1.05 Binding ≤ 10μM
5HT2C_HUMAN P28335 Serotonin 2c (5-HT2c) Receptor, Human 2697 0.78 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
G alpha (q) signalling events
Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
Serotonin receptors

Analogs ( Draw Identity 99% 90% 80% 70% )