| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 14th, 2008 | 34 | Yes |
4-(9-Chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)benzoic acid
4-(9-Chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)benzoicacid
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.27 | 12.65 | -57.45 | 1 | 6 | -1 | 90 | 475.862 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | Aurora Kinase | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ABL1-1-E | Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic | Eukaryotes | 820 | 0.25 | Binding ≤ 10μM |
| ABL2-1-E | Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3300 | 0.23 | Binding ≤ 10μM |
| AURKA-1-E | Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4 | 0.35 | Binding ≤ 10μM |
| AURKB-1-E | Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9 | 0.33 | Binding ≤ 10μM |
| AURKC-1-E | Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic | Eukaryotes | 26 | 0.31 | Binding ≤ 10μM |
| BLK-1-E | Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 68 | 0.30 | Binding ≤ 10μM |
| BMX-1-E | Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3100 | 0.23 | Binding ≤ 10μM |
| BTK-1-E | Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4200 | 0.22 | Binding ≤ 10μM |
| CLK2-1-E | Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3200 | 0.23 | Binding ≤ 10μM |
| CLK3-1-E | Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2300 | 0.23 | Binding ≤ 10μM |
| CSK-1-E | Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9000 | 0.21 | Binding ≤ 10μM |
| DDR1-1-E | Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4200 | 0.22 | Binding ≤ 10μM |
| EGFR-1-E | Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 6400 | 0.21 | Binding ≤ 10μM |
| EPHA1-1-E | Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1800 | 0.24 | Binding ≤ 10μM |
| EPHA2-1-E | Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 370 | 0.26 | Binding ≤ 10μM |
| EPHA3-1-E | Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2100 | 0.23 | Binding ≤ 10μM |
| EPHA4-1-E | Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 420 | 0.26 | Binding ≤ 10μM |
| EPHA5-1-E | Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1400 | 0.24 | Binding ≤ 10μM |
| EPHA6-1-E | Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 580 | 0.26 | Binding ≤ 10μM |
| EPHA7-1-E | Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.25 | Binding ≤ 10μM |
| EPHB1-1-E | Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 330 | 0.27 | Binding ≤ 10μM |
| EPHB3-1-E | Ephrin Type-B Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3500 | 0.22 | Binding ≤ 10μM |
| EPHB4-1-E | Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 560 | 0.26 | Binding ≤ 10μM |
| FAK2-1-E | Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.23 | Binding ≤ 10μM |
| FER-1-E | Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4400 | 0.22 | Binding ≤ 10μM |
| FGFR1-1-E | Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2400 | 0.23 | Binding ≤ 10μM |
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.24 | Binding ≤ 10μM |
| FGFR3-1-E | Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1300 | 0.24 | Binding ≤ 10μM |
| FGR-1-E | Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic | Eukaryotes | 220 | 0.27 | Binding ≤ 10μM |
| FYN-1-E | Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic | Eukaryotes | 1300 | 0.24 | Binding ≤ 10μM |
| HCK-1-E | Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1500 | 0.24 | Binding ≤ 10μM |
| IRAK3-1-E | Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1400 | 0.24 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 590 | 0.26 | Binding ≤ 10μM |
| LYN-1-E | Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1400 | 0.24 | Binding ≤ 10μM |
| MAPK5-1-E | MAP Kinase-activated Protein Kinase 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.33 | Binding ≤ 10μM |
| MERTK-1-E | Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic | Eukaryotes | 730 | 0.25 | Binding ≤ 10μM |
| PLK4-1-E | Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 410 | 0.26 | Binding ≤ 10μM |
| ROS1-1-E | Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3100 | 0.23 | Binding ≤ 10μM |
| SIK1-1-E | Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.24 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 800 | 0.25 | Binding ≤ 10μM |
| ST17A-1-E | Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic | Eukaryotes | 190 | 0.28 | Binding ≤ 10μM |
| ST17B-1-E | Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.33 | Binding ≤ 10μM |
| STK10-1-E | Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3700 | 0.22 | Binding ≤ 10μM |
| TEC-1-E | Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic | Eukaryotes | 730 | 0.25 | Binding ≤ 10μM |
| TIE1-1-E | Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1600 | 0.24 | Binding ≤ 10μM |
| TIE2-1-E | Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 300 | 0.27 | Binding ≤ 10μM |
| TNK1-1-E | Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2400 | 0.23 | Binding ≤ 10μM |
| TYRO3-1-E | Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3100 | 0.23 | Binding ≤ 10μM |
| UFO-1-E | Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic | Eukaryotes | 440 | 0.26 | Binding ≤ 10μM |
| VGFR1-1-E | Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.25 | Binding ≤ 10μM |
| VGFR3-1-E | Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3100 | 0.23 | Binding ≤ 10μM |
| YES-1-E | Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic | Eukaryotes | 260 | 0.27 | Binding ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 150 | 0.28 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 670 | 0.25 | Functional ≤ 10μM |
| Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other | Other | 790 | 0.25 | Functional ≤ 10μM |
| Z80493-1-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other | Other | 530 | 0.26 | Functional ≤ 10μM |
| Z80526-1-O | SW480 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 860 | 0.25 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 180 | 0.28 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| EPHA2_HUMAN | P29317 | Ephrin Type-A Receptor 2, Human | 370 | 0.26 | Binding ≤ 1μM |
| EPHA4_HUMAN | P54764 | Ephrin Type-A Receptor 4, Human | 420 | 0.26 | Binding ≤ 1μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 580 | 0.26 | Binding ≤ 1μM |
| EPHA7_HUMAN | Q15375 | Ephrin Type-A Receptor 7, Human | 1000 | 0.25 | Binding ≤ 1μM |
| EPHB1_HUMAN | P54762 | Ephrin Type-B Receptor 1, Human | 330 | 0.27 | Binding ≤ 1μM |
| EPHB4_HUMAN | P54760 | Ephrin Type-B Receptor 4, Human | 560 | 0.26 | Binding ≤ 1μM |
| MAPK5_HUMAN | Q8IW41 | MAP Kinase-activated Protein Kinase 5, Human | 8 | 0.33 | Binding ≤ 1μM |
| MERTK_HUMAN | Q12866 | Proto-oncogene Tyrosine-protein Kinase MER, Human | 730 | 0.25 | Binding ≤ 1μM |
| AURKB_MOUSE | O70126 | Serine/threonine-protein Kinase 12, Mouse | 172 | 0.28 | Binding ≤ 1μM |
| ST17A_HUMAN | Q9UEE5 | Serine/threonine-protein Kinase 17A, Human | 190 | 0.28 | Binding ≤ 1μM |
| ST17B_HUMAN | O94768 | Serine/threonine-protein Kinase 17B, Human | 8.1 | 0.33 | Binding ≤ 1μM |
| AURKA_MOUSE | P97477 | Serine/threonine-protein Kinase Aurora-A, Mouse | 4 | 0.35 | Binding ≤ 1μM |
| AURKA_HUMAN | O14965 | Serine/threonine-protein Kinase Aurora-A, Human | 1 | 0.37 | Binding ≤ 1μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 172 | 0.28 | Binding ≤ 1μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 26 | 0.31 | Binding ≤ 1μM |
| PLK4_HUMAN | O00444 | Serine/threonine-protein Kinase PLK4, Human | 410 | 0.26 | Binding ≤ 1μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 450 | 0.26 | Binding ≤ 1μM |
| BLK_HUMAN | P51451 | Tyrosine-protein Kinase BLK, Human | 68 | 0.30 | Binding ≤ 1μM |
| FGR_HUMAN | P09769 | Tyrosine-protein Kinase FGR, Human | 220 | 0.27 | Binding ≤ 1μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 590 | 0.26 | Binding ≤ 1μM |
| UFO_HUMAN | P30530 | Tyrosine-protein Kinase Receptor UFO, Human | 440 | 0.26 | Binding ≤ 1μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 800 | 0.25 | Binding ≤ 1μM |
| TEC_HUMAN | P42680 | Tyrosine-protein Kinase TEC, Human | 730 | 0.25 | Binding ≤ 1μM |
| TIE2_HUMAN | Q02763 | Tyrosine-protein Kinase TIE-2, Human | 300 | 0.27 | Binding ≤ 1μM |
| YES_HUMAN | P07947 | Tyrosine-protein Kinase YES, Human | 260 | 0.27 | Binding ≤ 1μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 1000 | 0.25 | Binding ≤ 1μM |
| CLK2_HUMAN | P49760 | Dual Specificity Protein Kinase CLK2, Human | 3200 | 0.23 | Binding ≤ 10μM |
| CLK3_HUMAN | P49761 | Dual Specificity Protein Kinase CLK3, Human | 2300 | 0.23 | Binding ≤ 10μM |
| EPHA1_HUMAN | P21709 | Ephrin Type-A Receptor 1, Human | 1800 | 0.24 | Binding ≤ 10μM |
| EPHA2_HUMAN | P29317 | Ephrin Type-A Receptor 2, Human | 370 | 0.26 | Binding ≤ 10μM |
| EPHA3_HUMAN | P29320 | Ephrin Type-A Receptor 3, Human | 2100 | 0.23 | Binding ≤ 10μM |
| EPHA4_HUMAN | P54764 | Ephrin Type-A Receptor 4, Human | 420 | 0.26 | Binding ≤ 10μM |
| EPHA5_HUMAN | P54756 | Ephrin Type-A Receptor 5, Human | 1400 | 0.24 | Binding ≤ 10μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 580 | 0.26 | Binding ≤ 10μM |
| EPHA7_HUMAN | Q15375 | Ephrin Type-A Receptor 7, Human | 1000 | 0.25 | Binding ≤ 10μM |
| EPHB1_HUMAN | P54762 | Ephrin Type-B Receptor 1, Human | 330 | 0.27 | Binding ≤ 10μM |
| EPHB3_HUMAN | P54753 | Ephrin Type-B Receptor 3, Human | 3500 | 0.22 | Binding ≤ 10μM |
| EPHB4_HUMAN | P54760 | Ephrin Type-B Receptor 4, Human | 560 | 0.26 | Binding ≤ 10μM |
| EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 3200 | 0.23 | Binding ≤ 10μM |
| DDR1_HUMAN | Q08345 | Epithelial Discoidin Domain-containing Receptor 1, Human | 4200 | 0.22 | Binding ≤ 10μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 2400 | 0.23 | Binding ≤ 10μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 1700 | 0.24 | Binding ≤ 10μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 1200 | 0.24 | Binding ≤ 10μM |
| IRAK3_HUMAN | Q9Y616 | Interleukin-1 Receptor-associated Kinase 3, Human | 1400 | 0.24 | Binding ≤ 10μM |
| MAPK5_HUMAN | Q8IW41 | MAP Kinase-activated Protein Kinase 5, Human | 8 | 0.33 | Binding ≤ 10μM |
| TNK1_HUMAN | Q13470 | Non-receptor Tyrosine-protein Kinase TNK1, Human | 2400 | 0.23 | Binding ≤ 10μM |
| FAK2_HUMAN | Q14289 | Protein Tyrosine Kinase 2 Beta, Human | 2000 | 0.23 | Binding ≤ 10μM |
| MERTK_HUMAN | Q12866 | Proto-oncogene Tyrosine-protein Kinase MER, Human | 730 | 0.25 | Binding ≤ 10μM |
| ROS1_HUMAN | P08922 | Proto-oncogene Tyrosine-protein Kinase ROS, Human | 3100 | 0.23 | Binding ≤ 10μM |
| STK10_HUMAN | O94804 | Serine/threonine-protein Kinase 10, Human | 3700 | 0.22 | Binding ≤ 10μM |
| AURKB_MOUSE | O70126 | Serine/threonine-protein Kinase 12, Mouse | 172 | 0.28 | Binding ≤ 10μM |
| ST17A_HUMAN | Q9UEE5 | Serine/threonine-protein Kinase 17A, Human | 190 | 0.28 | Binding ≤ 10μM |
| ST17B_HUMAN | O94768 | Serine/threonine-protein Kinase 17B, Human | 8.1 | 0.33 | Binding ≤ 10μM |
| AURKA_MOUSE | P97477 | Serine/threonine-protein Kinase Aurora-A, Mouse | 4 | 0.35 | Binding ≤ 10μM |
| AURKA_HUMAN | O14965 | Serine/threonine-protein Kinase Aurora-A, Human | 1 | 0.37 | Binding ≤ 10μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 172 | 0.28 | Binding ≤ 10μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 26 | 0.31 | Binding ≤ 10μM |
| PLK4_HUMAN | O00444 | Serine/threonine-protein Kinase PLK4, Human | 410 | 0.26 | Binding ≤ 10μM |
| SIK1_HUMAN | P57059 | Serine/threonine-protein Kinase SIK1, Human | 1700 | 0.24 | Binding ≤ 10μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 3600 | 0.22 | Binding ≤ 10μM |
| ABL2_HUMAN | P42684 | Tyrosine-protein Kinase ABL2, Human | 3300 | 0.23 | Binding ≤ 10μM |
| BLK_HUMAN | P51451 | Tyrosine-protein Kinase BLK, Human | 68 | 0.30 | Binding ≤ 10μM |
| BMX_HUMAN | P51813 | Tyrosine-protein Kinase BMX, Human | 3100 | 0.23 | Binding ≤ 10μM |
| BTK_HUMAN | Q06187 | Tyrosine-protein Kinase BTK, Human | 4200 | 0.22 | Binding ≤ 10μM |
| CSK_HUMAN | P41240 | Tyrosine-protein Kinase CSK, Human | 9000 | 0.21 | Binding ≤ 10μM |
| FER_HUMAN | P16591 | Tyrosine-protein Kinase FER, Human | 4400 | 0.22 | Binding ≤ 10μM |
| FGR_HUMAN | P09769 | Tyrosine-protein Kinase FGR, Human | 220 | 0.27 | Binding ≤ 10μM |
| FYN_HUMAN | P06241 | Tyrosine-protein Kinase FYN, Human | 1300 | 0.24 | Binding ≤ 10μM |
| HCK_HUMAN | P08631 | Tyrosine-protein Kinase HCK, Human | 1500 | 0.24 | Binding ≤ 10μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 3200 | 0.23 | Binding ≤ 10μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 1400 | 0.24 | Binding ≤ 10μM |
| TIE1_HUMAN | P35590 | Tyrosine-protein Kinase Receptor Tie-1, Human | 1600 | 0.24 | Binding ≤ 10μM |
| TYRO3_HUMAN | Q06418 | Tyrosine-protein Kinase Receptor TYRO3, Human | 3100 | 0.23 | Binding ≤ 10μM |
| UFO_HUMAN | P30530 | Tyrosine-protein Kinase Receptor UFO, Human | 440 | 0.26 | Binding ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 800 | 0.25 | Binding ≤ 10μM |
| TEC_HUMAN | P42680 | Tyrosine-protein Kinase TEC, Human | 730 | 0.25 | Binding ≤ 10μM |
| TIE2_HUMAN | Q02763 | Tyrosine-protein Kinase TIE-2, Human | 300 | 0.27 | Binding ≤ 10μM |
| YES_HUMAN | P07947 | Tyrosine-protein Kinase YES, Human | 260 | 0.27 | Binding ≤ 10μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 1000 | 0.25 | Binding ≤ 10μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 3100 | 0.23 | Binding ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 100 | 0.29 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 150 | 0.28 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 670 | 0.25 | Functional ≤ 10μM |
| Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 790 | 0.25 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 530 | 0.26 | Functional ≤ 10μM |
| Z80526 | Z80526 | SW480 (Colon Adenocarcinoma Cells) | 860 | 0.25 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins | |
| Apoptotic cleavage of cellular proteins | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| CDO in myogenesis | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CRMPs in Sema3A signaling | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| DCC mediated attractive signaling | |
| Downstream TCR signaling | |
| EGFR downregulation | |
| EGFR interacts with phospholipase C-gamma | |
| EGFR Transactivation by Gastrin | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| Factors involved in megakaryocyte development and platelet production | |
| Fc epsilon receptor (FCERI) signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| FCERI mediated NF-kB activation | |
| FCGR activation | |
| GAB1 signalosome | |
| Generation of second messenger molecules | |
| GPVI-mediated activation cascade | |
| GRB2 events in EGFR signaling | |
| GRB2 events in ERBB2 signaling | |
| Growth hormone receptor signaling | |
| Integrin alphaIIb beta3 signaling | |
| Interleukin-1 signaling | |
| Interleukin-2 signaling | |
| Interleukin-3, 5 and GM-CSF signaling | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| Mitotic Prometaphase | |
| MyD88:Mal cascade initiated on plasma membrane | |
| NCAM signaling for neurite out-growth | |
| Nef and signal transduction | |
| Nef Mediated CD4 Down-regulation | |
| Nephrin interactions | |
| Netrin mediated repulsion signals | |
| Neurophilin interactions with VEGF and VEGFR | |
| Non-integrin membrane-ECM interactions | |
| Oxidative Stress Induced Senescence | |
| PD-1 signaling | |
| PECAM1 interactions | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PI3K events in ERBB2 signaling | |
| PIP3 activates AKT signaling | |
| Platelet Adhesion to exposed collagen | |
| Platelet sensitization by LDL | |
| PLCG1 events in ERBB2 signaling | |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Regulation of KIT signaling | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Regulation of signaling by CBL | |
| Resolution of Sister Chromatid Cohesion | |
| Role of Abl in Robo-Slit signaling | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| Sema3A PAK dependent Axon repulsion | |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | |
| Separation of Sister Chromatids | |
| SHC1 events in EGFR signaling | |
| SHC1 events in ERBB2 signaling | |
| Signal regulatory protein (SIRP) family interactions | |
| Signal transduction by L1 | |
| Signaling by activated point mutants of FGFR1 | |
| Signaling by activated point mutants of FGFR3 | |
| Signaling by constitutively active EGFR | |
| Signaling by EGFR | |
| Signaling by ERBB2 | |
| Signaling by ERBB4 | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants | |
| Signaling by SCF-KIT | |
| t(4;14) translocations of FGFR3 | |
| Tie2 Signaling | |
| Translocation of ZAP-70 to Immunological synapse | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway |
No pre-computed analogs available. Try a structural similarity search.