| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 23rd, 2008 | 8 | Yes |
Popular Name: 2-Amino-6-methylpyridine 2-Amino-6-methylpyridine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1824-81-3 , [1824-81-3]
"2-Amino-6-methylpyridine, 98%"
2-Amino-6-(Trifluoromehtyl)Pyridine
2-amino-6-methylpyridine (2-amino-6-picoline)
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.57 | 2.09 | -4.82 | 2 | 2 | 0 | 39 | 108.144 | 0 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| BP [°C] | 208 - 209 | Acros Organics |
| Boiling_Point | 208-209? | Alfa-Aesar |
| Boiling_Point | 208-209° | Alfa-Aesar |
| BP | 209 | TCI |
| Mp [°C] | 40 - 45 | Acros Organics |
| Melting_Point | 41-45? | Alfa-Aesar |
| Melting_Point | 41-45° | Alfa-Aesar |
| MP | 41.5-45.5° | Oakwood Chemical |
| MP | 43 | TCI |
| Purity | 98% | Fluorochem |
| Purity | 99% | APIChem |
| H phrase | H311: Toxic in contact with skin | Acros Organics |
| H phrase | H311: Toxic in contact with skin; H315: Causes skin irritation; H319: Causes serious eye irritation; H301: Toxic if swallowed; H335: May cause respiratory irritation | Acros Organics |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician | Acros Organics |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician; P280: Wear protective gloves/protective clothing/eye protection/face protection; P312: Call a POISON CENTER or doctor/physician if you feel unwell; P302 + P350: IF ON SKIN: G | Acros Organics |
| R phrase | R24/25: Toxic in contact with skin and if swallowed. | Acros Organics |
| R phrase | R24/25: Toxic in contact with skin and if swallowed.; R36/37/38: Irritating to eyes, respiratory system and skin. | Acros Organics |
| S phrase | S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. | Acros Organics |
| S phrase | S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S28A: After contact with skin, wash immediately with plenty of water.; S37/39: Wear suitable gloves and eye/face protection.; S45: In case of accident or i | Acros Organics |
| Hazard | T: Toxic | Acros Organics |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NOS2-8-E | Nitric Oxide Synthase, Inducible (cluster #8 Of 9), Eukaryotic | Eukaryotes | 2000 | 1.00 | Binding ≤ 10μM |
| NOS3-6-E | Nitric Oxide Synthase, Endothelial (cluster #6 Of 7), Eukaryotic | Eukaryotes | 820 | 1.07 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NOS3_HUMAN | P29474 | Nitric-oxide Synthase, Endothelial, Human | 820 | 1.07 | Binding ≤ 1μM |
| NOS2_HUMAN | P35228 | Nitric Oxide Synthase, Inducible, Human | 2000 | 1.00 | Binding ≤ 10μM |
| NOS3_HUMAN | P29474 | Nitric-oxide Synthase, Endothelial, Human | 820 | 1.07 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| eNOS activation | |
| Nitric oxide stimulates guanylate cyclase | |
| NOSIP mediated eNOS trafficking | |
| NOSTRIN mediated eNOS trafficking | |
| Phagosomal maturation (early endosomal stage) | |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | |
| VEGFR2 mediated vascular permeability |
