UCSF

ZINC19361042

Substance Information

In ZINC since Heavy atoms Benign functionality
October 31st, 2008 28 Yes

Other Names:

(+-)-Meclizine

1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine

1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride

1-((4-Chlorophenyl)benzyl)-4-((m-tolyl)methyl)piperazine hydrochloride; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine hydrochloride; EINECS 252-932-4; LS-111208; Meclizine hydrochloride; Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-meth

1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine

1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine

1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine

1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride monohydrate; ANTIVERT; C25H27ClN2.HCl; LS-174354; MECLIZINE HCL; Meclizine Hydrochloride; Meclizine dihydrochloride monohydrate; Meclizine hydrochloride [USAN:JAN]; Piperazine, 1

1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine

1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine

1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine

1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine hydrochloride

1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine

1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride

1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine

1104-22-9 (di-hydrochloride)

1104-22-9; Meclozine dihydrochloride; Prestwick_534

31884-77-2; Antivert (TN); D01317; Meclizine dihydrochloride monohydrate; Meclizine hydrochloride (JAN/USP)

36236-67-6 (hydrochloride)

569-65-3

569-65-3; C07116; Meclizine; Meclozine

569-65-3; D08163; Meclizine; Meclozine (BAN); Nevidoxine (TN)

AB00053493

AC1L1H9K

AC1Q2IO5

Ancolan

Ancolon

Antivert

Antivert/25

Antivert/50

BAN); Meclizine HCl (FDA

Bonadettes

Bonadoxin

Bonamine

Bonine

BPBio1_000588

BRD-A50311610-300-05-4

BRN 0332002

BSPBio_000534

BSPBio_001949

C07116

C25H27ClN2

Calmonal

CHEMBL1623

Chiclida

CHLOROPHENYLPHENYLMETHYLMETHYLBENZYLPIPERAZINEDIHYDROCHLORID

CID4034

CPD000058736; Duremesin; SAM002548969

CPD000058736; Meclizine hydrochloride; SAM002548969

D08163

DAP000795

DB00737

Diadril

DivK1c_000407

Dramamine

Dramamine II

EINECS 209-323-3

FDA

Histamethine

Histamethizine

Histametizine

Histametizyn

Histametizyne

HSDB 3113

IDI1_000407

INN)

Itinerol

JAN

JAN)

KBio1_000407

KBio2_001371

KBio2_003939

KBio2_006507

KBio3_001449

KBioGR_000473

KBioSS_001371

L001136

LS-111206

LS-192217

Marex

Meclicot

Meclizine

Meclizine (dihydrochloride)

Meclizine 2HCl

Meclizine DiHCl

Meclizine dihydrochloride

Meclizine dihydrochloride monohydrate

Meclizine Hcl

Meclizine Hydrochloride (JAN

Meclizine [INN:BAN]

Meclizinedihydrochloride

Meclozina

Meclozina [INN-Spanish]

Meclozine

Meclozine (BAN)

Meclozine (INN

Meclozine dihydrochloride

Meclozinum

Meclozinum [INN-Latin]

Medivert

MFCD00058199

MFCD00242697

MFCD00941489

MolPort-002-069-043

Monamine

N/A

NA

Navicalm

Neo-Istafene

Neo-Suprimal

Neo-Suprimel

Nevidoxine

Nevidoxine (TN)

NINDS_000407

NSC 169189

NSC169189

Parachloramine

Peremesin

Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-

Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-

Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-

Postafene

Prestwick0_000457

Prestwick1_000457

Prestwick2_000457

Prestwick3_000457

QA-2598

Ravelon

Ru-Vert-M

Sabari

Sea-Legs

Siguran

SPBio_000100

SPBio_002473

Spectrum2_000110

Spectrum3_000485

Spectrum4_000037

Spectrum5_000919

Spectrum_000891

Subari

Suprimal

Travelon

U. C. B. 5062

U.C.B. 5062

UCB 170

UCB 5052

UCB 5062

UNII-3L5TQ84570

USP

USP)

USP); Meclozine (BAN

Veritab

Vomisseis

Vomissels

WLN: T6N DNTJ AYR&R DG& D1R C1

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.91 14.62 -39.76 1 2 1 8 391.966 5
Mid Mid (pH 6-8) 5.91 14.21 -37.35 1 2 1 8 391.966 5
Mid Mid (pH 6-8) 5.91 12.37 -3.17 0 2 0 6 390.958 5

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.03e-03 g/l DrugBank-approved
MP 231 - 233 Enamine Building Blocks
MP 231...233 Enamine Building Blocks
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity 95% Fluorochem
Purity 95+% Matrix Scientific
Therapy antiemetic SMDC Iconix
PUBCHEM_PATENT_ID EP0017439A1; EP0045996A1; EP0129284A2; EP0129285A2; EP0129285B1; EP0181721A1; EP0198392A1; EP0214724A1; EP0214724B1; EP0260952A2; EP0271679A2; EP0306191A2; EP0383124A2; EP0474501B1; EP0507143B1; EP0514159A1; EP0527835A1; EP0527835B1; EP0562705B1; EP056897 IBM Patent Data
Warnings IRRITANT Matrix Scientific
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : Enamine; NCC_SUPPLIER_STRUCTURE_ID : 36991575; 2 hydrogen chloride NIH Clinical Collection via PubChem
Target Others Selleck Chemicals
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: Enamine; SUPPLIER_STRUCTURE_ID: 36991575; SALT: 2 hydrogen chloride NIH Clinical Collection via PubChem

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )