UCSF

ZINC19364226

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 31st, 2008 31 Yes

Popular Name: Buclizine Buclizine

Find On: PubMed — Wikipedia — Google

CAS Numbers: 129-74-8 , 82-95-1 , [129-74-8]

Other Names:

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazinedihydrochloride

1-(4-Tert-butylbenzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine

1-(4-tert-butylbenzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine; 129-74-8; nsc25141

1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine

1-(p-Chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediamine dihydrochloride; 1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine dihydrochloride; 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride; 1-p-Chlorobenzhydry

1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine

1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine; Buclizine

1-[(4-chlorophenyl)(phenyl)methyl]-4-{[4-(1,1-dimethylethyl)phenyl]methyl}piperazine

1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine

129-74-8

129-74-8 (di-hydrochloride)

129-74-8; Buclizine hydrochloride (USAN); D02089; Vibazine (TN)

4-23-00-00082 (Beilstein Handbook Reference)

82-95-1

82-95-1; Buclina (TN); Buclizine (INN); D07547

82-95-1; Buclizine; C07777

87994-02-3

AC-15954

AC1L1N6A

AC1Q3ND3

Acetaminophen, mixture with buclizine, codeine and dioctylsodiumsulphosuccinate; LS-91934; Migraleve; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-alpha)-, phosphate (1:1) (salt), mixt. with sodium 1,4-bis(2-ethylhexyl)sulfobut

AH 2526

Aphilan R

Aphilan-R Base

AR-1I0822

BRN 0349567

Bucladin

Bucladin-S

Buclifen

Buclina

Buclina (TN)

Buclizina

Buclizina [INN-Spanish]

Buclizina [INN-Spanish];Buclizinum [INN-Latin]

buclizina; buclizine; buclizinum

Buclizine (BAN

Buclizine (INN)

Buclizine 2HCl

Buclizine dihydrochloride

Buclizine HCl

Buclizine Hydrochloride

Buclizine Hydrochloride (*dihydrochloride*)

Buclizine [INN:BAN]

buclizine(2+)

Buclizine, hydrochloride

Buclizinum

Buclizinum [INN-Latin]

Buclodin

C07777

C28H33ClN2

CHEBI:3205

CID6729

component of Bucladin-S

component of Softran

D07547

DAP001076

DB00354

EINECS 201-448-1

Histabuticine

Histabutizine

Histabutyzine

Histabutyzine Dihydrochloride

Histabutyzine Hydrochloride

Hitabutyzyne

INN); Buclizine HCl (FDA

INN); Buclizine Hydrochloride (FDA

L000971

Longifene

LS-110571

MFCD00242700

MolPort-003-845-425

N/A

NCI60_002006

NSC25141

Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-

Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)- (9CI)

PIPERAZINE, 1-(p-tert-BUTYLBENZYL)-4-(p-CHLORO-alpha-PHENYLBENZYL)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride

Posdel

Postafen

Softran

UCB 4445

UCB-4445

UNII-0C94V6X681

USAN)

Vibazine

Vibazine Hydrochloride

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 7.19 16.42 -39.97 1 2 1 8 434.047 6 ↓
Mid Mid (pH 6-8) 7.19 14.1 -2.83 0 2 0 6 433.039 6 ↓
Mid Mid (pH 6-8) 7.19 15.9 -37.54 1 2 1 8 434.047 6 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 2.46e-04 g/l DrugBank-approved
Indications antihistamine KeyOrganics Bioactives
Patent Database Links EP1832287; US2006040900; US2007265234; WO2005099702; WO2007109523 ChEBI
Target Histamine Recepto Selleck Chemicals

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Analogs ( Draw Identity 99% 90% 80% 70% )