| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 31st, 2008 | 31 | Yes |
Popular Name: Buclizine Buclizine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 129-74-8 , 82-95-1 , [129-74-8]
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazinedihydrochloride
1-(4-Tert-butylbenzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine
1-(4-tert-butylbenzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine; 129-74-8; nsc25141
1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine
1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine; Buclizine
1-[(4-chlorophenyl)(phenyl)methyl]-4-{[4-(1,1-dimethylethyl)phenyl]methyl}piperazine
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine
129-74-8; Buclizine hydrochloride (USAN); D02089; Vibazine (TN)
4-23-00-00082 (Beilstein Handbook Reference)
82-95-1; Buclina (TN); Buclizine (INN); D07547
Buclizina [INN-Spanish];Buclizinum [INN-Latin]
buclizina; buclizine; buclizinum
Buclizine Hydrochloride (*dihydrochloride*)
INN); Buclizine Hydrochloride (FDA
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)- (9CI)
PIPERAZINE, 1-(p-tert-BUTYLBENZYL)-4-(p-CHLORO-alpha-PHENYLBENZYL)-
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 7.19 | 16.28 | -39.71 | 1 | 2 | 1 | 8 | 434.047 | 6 | ↓ |
| Mid Mid (pH 6-8) | 7.19 | 14.03 | -2.78 | 0 | 2 | 0 | 6 | 433.039 | 6 | ↓ |
| Mid Mid (pH 6-8) | 7.19 | 15.87 | -36.94 | 1 | 2 | 1 | 8 | 434.047 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 2.46e-04 g/l | DrugBank-approved |
| Indications | antihistamine | KeyOrganics Bioactives |
| PUBCHEM_PATENT_ID | EP0098041A2; EP0271489A1; EP0349657A1; EP0428772A1; EP0758895B1; EP0978282A3; US4017614; US4758433; US4889850; US5053396; US5273759; US5612053; US5738865; US5770606; US5795909; US5922744; US5945117; US5962009; US5985889; US6087362; US6121276; US6140324; W | IBM Patent Data |
| Patent Database Links | EP1832287; US2006040900; US2007265234; WO2005099702; WO2007109523 | ChEBI |
| Target | Histamine Recepto | Selleck Chemicals |
