| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 4th, 2008 | 23 | Yes |
Popular Name: Enoxacin Enoxacin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 104142-71-4 , 74011-58-8 , 84294-96-2 , [74011-58-8]
1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
1,8-Naphthyridine-3-carboxylic acid, 6-fluoro-1,4-dihydro- 4-oxo-7-piperazinyl
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7- [1-piperazinyl]-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylicacid
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid
74011-58-8; D00310; ENX; Enoxacin (USAN/INN); Penetrex (TN)
74011-58-8; Enoxacin; Prestwick_708
84294-96-2; D05461; Enoxacin hydrate (JP16)
Almitil, Bactidan, Bactidron, Comprecin, Enoksetin, Enoxen, Enroxil, Enoxin, Enoxor, Flumark, Gyrami
enoxacin; enoxacine; enoxacino; enoxacinum
Pierre Fabre Brand of Enoxacin Sesquihydrate
Rhone Poulenc Rorer Brand of Enoxacin Sesquihydrate
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.38 | 8.61 | -95.06 | 2 | 7 | 0 | 95 | 320.324 | 3 | ↓ |
| Hi High (pH 8-9.5) | -0.38 | 7.3 | -57.43 | 1 | 7 | -1 | 90 | 319.316 | 3 | ↓ |
| Lo Low (pH 4.5-6) | -3.97 | 7.35 | -79.58 | 3 | 7 | 1 | 98 | 321.332 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Molecular_Solubility | 2.037 | Bitter DB |
| ALOGPS_SOLUBILITY | 1.09e+00 g/l | DrugBank-approved |
| MP | 226 | TCI |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 99% | Fluorochem |
| Therapy | antibacterial | SMDC Pharmakon |
| UniProt Database Links | MDTH_ECO24; MDTH_ECO27; MDTH_ECO45; MDTH_ECO55; MDTH_ECO57; MDTH_ECO5E; MDTH_ECO7I; MDTH_ECO81; MDTH_ECO8A; MDTH_ECOBW; MDTH_ECODH; MDTH_ECOHS; MDTH_ECOK1; MDTH_ECOL5; MDTH_ECOL6; MDTH_ECOLC; MDTH_ECOLI; MDTH_ECOLU; MDTH_ECOSE; MDTH_ECOSM; MDTH_ECOUT; MDT | ChEBI |
| Target | Others | Selleck Chemicals |
| Target | Topoisomerase | Selleck Chemicals |
| Indications | urinary tract infection | KeyOrganics Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| VATB2-1-E | V-type Proton ATPase Subunit B, Brain Isoform (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10000 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| VATB2_HUMAN | P21281 | V-type Proton ATPase Subunit B, Brain Isoform, Human | 10000 | 0.30 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Insulin receptor recycling | |
| Phagosomal maturation (early endosomal stage) | |
| Transferrin endocytosis and recycling |
