Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.48	2.33	-17.11	0	7	0	78	320.393	8	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	-2.00	2.61	-51.99	1	7	1	80	321.401	8	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE4A-3-E	Phosphodiesterase 4A (cluster #3 Of 3), Eukaryotic	Eukaryotes	170	0.41	Binding ≤ 10μM
PDE4B-2-E	Phosphodiesterase 4B (cluster #2 Of 2), Eukaryotic	Eukaryotes	170	0.41	Binding ≤ 10μM
PDE4C-2-E	Phosphodiesterase 4C (cluster #2 Of 2), Eukaryotic	Eukaryotes	170	0.41	Binding ≤ 10μM
PDE4D-2-E	Phosphodiesterase 4D (cluster #2 Of 2), Eukaryotic	Eukaryotes	170	0.41	Binding ≤ 10μM
Z50512-5-O	Cavia Porcellus (cluster #5 Of 7), Other	Other	10	0.49	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE4A_HUMAN	P27815	Phosphodiesterase 4A, Human	0.17	0.59	Binding ≤ 1μM
PDE4B_HUMAN	Q07343	Phosphodiesterase 4B, Human	0.17	0.59	Binding ≤ 1μM
PDE4C_HUMAN	Q08493	Phosphodiesterase 4C, Human	0.17	0.59	Binding ≤ 1μM
PDE4D_HUMAN	Q08499	Phosphodiesterase 4D, Human	0.17	0.59	Binding ≤ 1μM
PDE4A_HUMAN	P27815	Phosphodiesterase 4A, Human	0.17	0.59	Binding ≤ 10μM
PDE4B_HUMAN	Q07343	Phosphodiesterase 4B, Human	0.17	0.59	Binding ≤ 10μM
PDE4C_HUMAN	Q08493	Phosphodiesterase 4C, Human	0.17	0.59	Binding ≤ 10μM
PDE4D_HUMAN	Q08499	Phosphodiesterase 4D, Human	0.17	0.59	Binding ≤ 10μM
Z50512	Z50512	Cavia Porcellus	10	0.49	Functional ≤ 10μM