UCSF

ZINC02011568

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 10th, 2004 23 Yes

Popular Name: Mequitazine Mequitazine

Find On: PubMed — Wikipedia — Google

CAS Numbers: 147780-50-5 , 29216-28-2

Other Names:

(R)-(+)-Mequitazine

10-(1-Aza-bicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine

10-(1-azabicyclo(2.2.2)oct-8-ylmethyl)phenothiazine

10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine

10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine; 29216-28-2; nsc303612

10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine

10-(3-Quinuclidinylmethyl)phenothiazine

10-(3-Quinuclidinylmethyl)phenothiazine; 10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-; 3-methylquinuclidinyl-10-phenothiazine; BRN 1150945; C20H22N2S; EINECS 249-521-7; Instotal; LM 209; LM-209; LS-105668; Mequitazina [INN-Spanish]; Mequitaz

10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-

10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)- (9CI)

10H-Phenothiazine, 10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)-

29216-28-2

29216-28-2; D01324; Kitazemin (TN); Mequitazine (JP16/INN)

3-Methylquinuclidinyl-10-phenothiazine

84992-84-7 (hydrochloride)

AC-2365

AC1L1HC7

AC1Q7G50

AKOS000424971

AR-1I1105

Bio-0800

BRN 1150945

Butix

C006069

C12755

C20H22N2S

CHEMBL73451

CID4066

D01324

DAP001078

DB01071

EINECS 249-521-7

I06-1052

Instotal

Italfarmaco brand of mequitazine

Kitazemin

Kitazemin (TN)

L000704

LM 209

LM 209; Virginan; Mequitazine; 10-(3-Quinuclidinylmethyl)phenothiazine

LM-209

LS-105668

Mequitazina

Mequitazina [INN-Spanish]

Mequitazina [INN-Spanish];Mequitazina [Spanish];Mequitazinum [INN-Latin]

Mequitazina [Spanish]

Mequitazine (JP15/INN)

mequitazine hydrochloride

mequitazine tartrate, (R-(R*,R*))-isomer

Mequitazine [INN:BAN:DCF:JAN]

Mequitazinum

Mequitazinum [INN-Latin]

Metaplexan

MFCD01706743

Mircol

MLS000757058

MLS001201790

MolPort-002-663-305

NCI60_002566

NSC 303612

NSC303612

Phenothiazine, 10-(3-quinuclidinylmethyl)-

Pierre Fabre brand of mequitazine

Primalan

Quitadrill

SMR000528898

STK324459

Vigigan

Virginan

Zesulan

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.11 12.08 -34.86 1 2 1 9 323.485 2 ↓

Vendor Notes

Note Type Comments Provided By
mechanism . ZereneX Building Blocks
ALOGPS_SOLUBILITY 4.01e-03 g/l DrugBank-approved
biological_use Antiallergic agent IBScreen Bioactives
PUBCHEM_PATENT_ID EP0089860A1; EP0159059A1; EP0311677A1; EP0311677B1; EP0315079A1; EP0315079B1; EP0316434A1; EP0316434B2; EP0345931A1; EP0345931B1; EP0354301A2; EP0402422A1; EP0411629A2; EP0411629B1; EP0443027B1; EP0446636B1; EP0484529A1; EP0484529B1; EP0497977B1; EP055639 IBM Patent Data
mechanism Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. IBScreen Bioactives
mechanism This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine IBScreen Bioactives

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )