Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.58	7.92	-37.82	2	3	1	43	236.335	7	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.58	6.69	-5.41	1	3	0	38	235.327	7	↓ MOL2 SDF SMILES Flexibase

Note Type	Comments	Provided By
PUBCHEM_PATENT_ID	EP0218446A2; EP0218446B1; EP0681483A1; EP0682514A1; EP0848948A1; EP0932416A2; EP0934083A1; EP0941077A1; EP0958364A1; EP0963202A1; EP0979085A1; EP0999839A1; EP1021204A2; EP1022019A1; EP1027015A1; EP1043030A1; EP1043031A1; US4024223; US4041174; US4495174; U	IBM Patent Data
Therapy	local anesthetic, 5HT2 agonist	SMDC Pharmakon

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
SCN1A-2-E	Sodium Channel Protein Type I Alpha Subunit (cluster #2 Of 2), Eukaryotic	Eukaryotes	7600	0.42	Binding ≤ 10μM
SCN2A-2-E	Sodium Channel Protein Type II Alpha Subunit (cluster #2 Of 2), Eukaryotic	Eukaryotes	7600	0.42	Binding ≤ 10μM
SCN3A-2-E	Sodium Channel Protein Type III Alpha Subunit (cluster #2 Of 2), Eukaryotic	Eukaryotes	7600	0.42	Binding ≤ 10μM
SCN8A-2-E	Sodium Channel Protein Type VIII Alpha Subunit (cluster #2 Of 2), Eukaryotic	Eukaryotes	7600	0.42	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
SCN1A_HUMAN	P35498	Sodium Channel Protein Type I Alpha Subunit, Human	7600	0.42	Binding ≤ 10μM
SCN2A_HUMAN	Q99250	Sodium Channel Protein Type II Alpha Subunit, Human	7600	0.42	Binding ≤ 10μM
SCN3A_HUMAN	Q9NY46	Sodium Channel Protein Type III Alpha Subunit, Human	7600	0.42	Binding ≤ 10μM
SCN8A_HUMAN	Q9UQD0	Sodium Channel Protein Type VIII Alpha Subunit, Human	7600	0.42	Binding ≤ 10μM

Description	Species
Interaction between L1 and Ankyrins	Homo sapiens (SCN1A_HUMAN)