Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	-1.40	8.04	-139.2	5	17	-2	263	680.756	20	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	-1.40	6.51	-67.12	6	17	-1	260	681.764	20	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CATB-1-E	Cathepsin B (cluster #1 Of 6), Eukaryotic	Eukaryotes	9500	0.15	Binding ≤ 10μM
CEL2A-2-E	Elastase 2A (cluster #2 Of 2), Eukaryotic	Eukaryotes	2200	0.17	Binding ≤ 10μM
CELA1-1-E	Elastase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.17	Binding ≤ 10μM
ELNE-2-E	Neutrophil Elastase (cluster #2 Of 3), Eukaryotic	Eukaryotes	6700	0.15	Binding ≤ 10μM
A3EZI9-2-V	Hepatitis C Virus NS3 Protease/helicase (cluster #2 Of 3), Viral	Viruses	1100	0.17	Binding ≤ 10μM
D2K2A8-1-V	Hepatitis C Virus NS4A Protein (cluster #1 Of 1), Viral	Viruses	1100	0.17	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
CATB_HUMAN	P07858	Cathepsin B, Human	9500	0.15	Binding ≤ 10μM
CELA1_PIG	P00772	Elastase 1, Pig	2200	0.17	Binding ≤ 10μM
CEL2A_PIG	P08419	Elastase 2A, Pig	2200	0.17	Binding ≤ 10μM
A3EZI9_9HEPC	A3EZI9	Hepatitis C Virus NS3 Protease/helicase, 9hepc	1100	0.17	Binding ≤ 10μM
D2K2A8_9HEPC	D2K2A8	Hepatitis C Virus NS4A Protein, 9hepc	1100	0.17	Binding ≤ 10μM
ELNE_HUMAN	P08246	Leukocyte Elastase, Human	6700	0.15	Binding ≤ 10μM

Description	Species
Activation of Matrix Metalloproteinases	Homo sapiens (ELNE_HUMAN)
Assembly of collagen fibrils and other multimeric structures	Homo sapiens (CATB_HUMAN)
Collagen degradation	Homo sapiens (CATB_HUMAN)
Degradation of the extracellular matrix	Homo sapiens (ELNE_HUMAN)
MHC class II antigen presentation	Homo sapiens (CATB_HUMAN)
Trafficking and processing of endosomal TLR	Homo sapiens (CATB_HUMAN)