| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 9th, 2009 | 23 | No |
Popular Name: 4-cyclopropyl-7-nitro-6-pyrrol-1-yl-1H-quinoxaline-2,3-dione 4-cyclopropyl-7-nitro-6-pyrrol-1…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.16 | 8.51 | -14.53 | 1 | 8 | 0 | 106 | 312.285 | 3 | ↓ |
| Hi High (pH 8-9.5) | 2.06 | 7.45 | -38.91 | 0 | 8 | -1 | 109 | 311.277 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-2-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA2-1-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA3-1-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA4-1-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 3500 | 0.33 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA2_MOUSE | P23819 | Glutamate Receptor Ionotropic, AMPA 2, Mouse | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA3_MOUSE | Q9Z2W9 | Glutamate Receptor Ionotropic, AMPA 3, Mouse | 3500 | 0.33 | Binding ≤ 10μM |
| GRIA4_MOUSE | Q9Z2W8 | Glutamate Receptor Ionotropic, AMPA 4, Mouse | 3500 | 0.33 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
