| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 10th, 2009 | 38 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.09 | 6.53 | -69.99 | 5 | 10 | 1 | 142 | 537.666 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KLKB1-1-E | Plasma Kallikrein (cluster #1 Of 3), Eukaryotic | Eukaryotes | 7300 | 0.19 | Binding ≤ 10μM |
| PLMN-2-E | Plasminogen (cluster #2 Of 2), Eukaryotic | Eukaryotes | 4900 | 0.20 | Binding ≤ 10μM |
| PLMN-2-E | Plasminogen (cluster #2 Of 2), Eukaryotic | Eukaryotes | 6100 | 0.19 | Binding ≤ 10μM |
| THRB-1-E | Prothrombin (cluster #1 Of 8), Eukaryotic | Eukaryotes | 4 | 0.31 | Binding ≤ 10μM |
| THRB-1-E | Prothrombin (cluster #1 Of 8), Eukaryotic | Eukaryotes | 9 | 0.30 | Binding ≤ 10μM |
| TRY2-1-E | Trypsin II (cluster #1 Of 3), Eukaryotic | Eukaryotes | 97 | 0.26 | Binding ≤ 10μM |
| TRY2-1-E | Trypsin II (cluster #1 Of 3), Eukaryotic | Eukaryotes | 170 | 0.25 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| THRB_BOVIN | P00735 | Thrombin, Bovin | 4 | 0.31 | Binding ≤ 1μM |
| TRY2_BOVIN | Q29463 | Trypsin II, Bovin | 97 | 0.26 | Binding ≤ 1μM |
| KLKB1_HUMAN | P03952 | Plasma Kallikrein, Human | 7300 | 0.19 | Binding ≤ 10μM |
| PLMN_HUMAN | P00747 | Plasminogen, Human | 4900 | 0.20 | Binding ≤ 10μM |
| THRB_BOVIN | P00735 | Thrombin, Bovin | 4 | 0.31 | Binding ≤ 10μM |
| TRY2_BOVIN | Q29463 | Trypsin II, Bovin | 97 | 0.26 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Cell surface interactions at the vascular wall | |
| Common Pathway | |
| Degradation of the extracellular matrix | |
| Dissolution of Fibrin Clot | |
| G alpha (q) signalling events | |
| Gamma-carboxylation of protein precursors | |
| Intrinsic Pathway | |
| Peptide ligand-binding receptors | |
| Platelet Aggregation (Plug Formation) | |
| Platelet degranulation | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Signaling by PDGF | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
