Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.11	7.98	-36.31	2	3	1	34	292.443	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.11	5.69	-5.12	1	3	0	33	291.435	6	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
Q9WTR4-1-E	Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic	Eukaryotes	220	0.44	Binding ≤ 10μM
SC6A2-2-E	Norepinephrine Transporter (cluster #2 Of 2), Eukaryotic	Eukaryotes	1800	0.38	Binding ≤ 10μM
SC6A3-1-E	Dopamine Transporter (cluster #1 Of 3), Eukaryotic	Eukaryotes	3500	0.36	Binding ≤ 10μM
SC6A4-3-E	Serotonin Transporter (cluster #3 Of 4), Eukaryotic	Eukaryotes	30	0.50	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
SC6A3_RAT	P23977	Dopamine Transporter, Rat	640	0.41	Binding ≤ 1μM
Q9WTR4_RAT	Q9WTR4	Norepinephrine Transporter, Rat	220	0.44	Binding ≤ 1μM
SC6A4_RAT	P31652	Serotonin Transporter, Rat	30	0.50	Binding ≤ 1μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	30	0.50	Binding ≤ 1μM
SC6A3_HUMAN	Q01959	Dopamine Transporter, Human	3500	0.36	Binding ≤ 10μM
SC6A3_RAT	P23977	Dopamine Transporter, Rat	640	0.41	Binding ≤ 10μM
Q9WTR4_RAT	Q9WTR4	Norepinephrine Transporter, Rat	220	0.44	Binding ≤ 10μM
SC6A2_HUMAN	P23975	Norepinephrine Transporter, Human	1800	0.38	Binding ≤ 10μM
SC6A4_RAT	P31652	Serotonin Transporter, Rat	30	0.50	Binding ≤ 10μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	30	0.50	Binding ≤ 10μM

Description	Species
Dopamine clearance from the synaptic cleft	Rattus norvegicus (SC6A3_RAT) Homo sapiens (SC6A3_HUMAN)
Na+/Cl- dependent neurotransmitter transporters	Rattus norvegicus (SC6A3_RAT) Homo sapiens (SC6A2_HUMAN)