UCSF

ZINC28096582

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Substance Information

In ZINC since Heavy atoms Benign functionality
February 24th, 2009 23 Yes

Popular Name: 4-hydroxy-2-methyl-N-(4-methylthiazol-2-yl)-1,1-dioxo-benzo[e]thiazine-3-carboxamide 4-hydroxy-2-methyl-N-(4-methylth…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.24 3.7 -49.22 1 7 -1 102 350.401 2 ↓
Lo Low (pH 4.5-6) 1.06 3.79 -47.29 1 7 -1 102 350.401 2 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
PGH1-1-E Cyclooxygenase-1 (cluster #1 Of 6), Eukaryotic Eukaryotes 6760 0.31 Binding ≤ 10μM
PGH2-1-E Cyclooxygenase-2 (cluster #1 Of 8), Eukaryotic Eukaryotes 830 0.37 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
PGH2_HUMAN P35354 Cyclooxygenase-2, Human 830 0.37 Binding ≤ 1μM
PGH1_HUMAN P23219 Cyclooxygenase-1, Human 6760 0.31 Binding ≤ 10μM
PGH2_HUMAN P35354 Cyclooxygenase-2, Human 830 0.37 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
COX reactions
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.