Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.22	3.76	-104.78	10	9	2	168	497.64	10	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	0.22	3.58	-68.73	9	9	1	166	496.632	10	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	1	0.35	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	17	0.30	Binding ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	7870	0.20	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_PIG	P79291	Delta Opioid Receptor, Pig	0.71	0.36	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.71	0.36	Binding ≤ 1μM
OPRM_MOUSE	P42866	Mu Opioid Receptor, Mouse	17	0.30	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	17	0.30	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.71	0.36	Binding ≤ 10μM
OPRD_PIG	P79291	Delta Opioid Receptor, Pig	0.71	0.36	Binding ≤ 10μM
OPRM_MOUSE	P42866	Mu Opioid Receptor, Mouse	17	0.30	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	17	0.30	Binding ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	7870	0.20	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Sus scrofa (OPRD_PIG) Rattus norvegicus (OPRD_RAT) Mus musculus (OPRM_MOUSE)
G-protein activation	Mus musculus (OPRM_MOUSE) Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Mus musculus (OPRM_MOUSE) Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Rattus norvegicus (OPRD_RAT) Mus musculus (OPRM_MOUSE) Sus scrofa (OPRD_PIG)