| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 1st, 2009 | 35 | Yes |
Popular Name: N-[(7-carbamimidoyl-2-naphthyl)methyl]-N-[2-(2-pyridyl)ethyl]naphthalene-1-carboxamide N-[(7-carbamimidoyl-2-naphthyl)m…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.64 | 13.72 | -40.93 | 4 | 5 | 1 | 85 | 459.573 | 7 | ↓ |
| Lo Low (pH 4.5-6) | 3.64 | 14.1 | -83.43 | 5 | 5 | 2 | 86 | 460.581 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FA10-2-E | Coagulation Factor X (cluster #2 Of 2), Eukaryotic | Eukaryotes | 104 | 0.28 | Binding ≤ 10μM |
| FA7-1-E | Coagulation Factor VII (cluster #1 Of 1), Eukaryotic | Eukaryotes | 195 | 0.27 | Binding ≤ 10μM |
| THRB-1-E | Prothrombin (cluster #1 Of 8), Eukaryotic | Eukaryotes | 4764 | 0.21 | Binding ≤ 10μM |
| TRY1-1-E | Trypsin I (cluster #1 Of 5), Eukaryotic | Eukaryotes | 299 | 0.26 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FA7_HUMAN | P08709 | Coagulation Factor VII, Human | 195 | 0.27 | Binding ≤ 1μM |
| FA10_HUMAN | P00742 | Coagulation Factor X, Human | 104 | 0.28 | Binding ≤ 1μM |
| TRY1_BOVIN | P00760 | Trypsin I, Bovin | 299 | 0.26 | Binding ≤ 1μM |
| FA7_HUMAN | P08709 | Coagulation Factor VII, Human | 195 | 0.27 | Binding ≤ 10μM |
| FA10_HUMAN | P00742 | Coagulation Factor X, Human | 104 | 0.28 | Binding ≤ 10μM |
| THRB_HUMAN | P00734 | Thrombin, Human | 4764 | 0.21 | Binding ≤ 10μM |
| TRY1_BOVIN | P00760 | Trypsin I, Bovin | 299 | 0.26 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Cell surface interactions at the vascular wall | |
| Common Pathway | |
| Extrinsic Pathway | |
| G alpha (q) signalling events | |
| Gamma-carboxylation of protein precursors | |
| Intrinsic Pathway | |
| Peptide ligand-binding receptors | |
| Platelet Aggregation (Plug Formation) | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
