Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.14	14.63	-82.66	2	4	2	27	398.591	11	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	5.14	12.1	-38.29	1	4	1	26	397.583	11	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
HRH3-2-E	Histamine H3 Receptor (cluster #2 Of 3), Eukaryotic	Eukaryotes	1	0.43	Binding ≤ 10μM
SC6A2-2-E	Norepinephrine Transporter (cluster #2 Of 2), Eukaryotic	Eukaryotes	201	0.32	Binding ≤ 10μM
SC6A4-1-E	Serotonin Transporter (cluster #1 Of 4), Eukaryotic	Eukaryotes	1	0.43	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
HRH3_HUMAN	Q9Y5N1	Histamine H3 Receptor, Human	0.6	0.45	Binding ≤ 1μM
SC6A2_HUMAN	P23975	Norepinephrine Transporter, Human	201	0.32	Binding ≤ 1μM
SC6A4_RAT	P31652	Serotonin Transporter, Rat	1	0.43	Binding ≤ 1μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	0.72	0.44	Binding ≤ 1μM
HRH3_HUMAN	Q9Y5N1	Histamine H3 Receptor, Human	0.6	0.45	Binding ≤ 10μM
SC6A2_HUMAN	P23975	Norepinephrine Transporter, Human	201	0.32	Binding ≤ 10μM
SC6A4_RAT	P31652	Serotonin Transporter, Rat	1	0.43	Binding ≤ 10μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	0.72	0.44	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (HRH3_HUMAN)
Histamine receptors	Homo sapiens (HRH3_HUMAN)
Na+/Cl- dependent neurotransmitter transporters	Homo sapiens (SC6A2_HUMAN)