| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 11th, 2009 | 22 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.05 | 4.64 | -44.97 | 3 | 7 | 0 | 111 | 307.398 | 4 | ↓ |
| Mid Mid (pH 6-8) | -0.05 | 4.51 | -86.82 | 2 | 7 | -1 | 110 | 306.39 | 4 | ↓ |
| Lo Low (pH 4.5-6) | -0.05 | 5.41 | -39.26 | 3 | 7 | 0 | 111 | 307.398 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-3-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA2-3-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA3-3-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA4-3-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 1350 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA3_HUMAN | P42263 | Glutamate Receptor Ionotropic, AMPA 3, Human | 1350 | 0.37 | Binding ≤ 10μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 1350 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
