In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 23rd, 2009 | 26 | Yes |
Popular Name: 2-[4-bromo-2-[1-(4-chlorophenyl)pyrazole-4-carbonyl]phenoxy]acetic 2-[4-bromo-2-[1-(4-chlorophenyl)…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.76 | 11.25 | -49.05 | 0 | 6 | -1 | 84 | 434.653 | 6 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GPR44-1-E | G Protein-coupled Receptor 44 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.47 | Binding ≤ 10μM |
GPR44-1-E | G Protein-coupled Receptor 44 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 17 | 0.42 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
GPR44_HUMAN | Q9Y5Y4 | G Protein-coupled Receptor 44, Human | 1.5 | 0.48 | Binding ≤ 1μM |
GPR44_HUMAN | Q9Y5Y4 | G Protein-coupled Receptor 44, Human | 1.5 | 0.48 | Binding ≤ 10μM |
GPR44_HUMAN | Q9Y5Y4 | G Protein-coupled Receptor 44, Human | 17 | 0.42 | Functional ≤ 10μM |
Description | Species |
---|---|
G alpha (i) signalling events | |
Prostanoid ligand receptors |