Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.79	9.61	-35.66	3	5	1	67	418.492	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.79	9.02	-13.44	2	5	0	65	417.484	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CCKAR-1-E	Cholecystokinin A Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.28	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	7	0.37	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	7	0.37	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	7	0.37	Binding ≤ 10μM
SGMR1-1-E	Sigma Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	7	0.37	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
CCKAR_RAT	P30551	Cholecystokinin A Receptor, Rat	600	0.28	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	7	0.37	Binding ≤ 1μM
OPRK_RAT	P34975	Kappa Opioid Receptor, Rat	7	0.37	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	7	0.37	Binding ≤ 1μM
SGMR1_RAT	Q9R0C9	Sigma Opioid Receptor, Rat	7	0.37	Binding ≤ 1μM
CCKAR_RAT	P30551	Cholecystokinin A Receptor, Rat	600	0.28	Binding ≤ 10μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	7	0.37	Binding ≤ 10μM
OPRK_RAT	P34975	Kappa Opioid Receptor, Rat	7	0.37	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	7	0.37	Binding ≤ 10μM
SGMR1_RAT	Q9R0C9	Sigma Opioid Receptor, Rat	7	0.37	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Rattus norvegicus (OPRD_RAT)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Rattus norvegicus (OPRD_RAT)