Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.89	7.57	-18.53	5	7	0	118	465.557	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.89	7.83	-62.73	6	7	1	120	466.565	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.89	7.9	-40.44	6	7	1	119	466.565	6	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	23	0.31	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	155	0.27	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	1.3	0.36	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	23	0.31	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	1.3	0.36	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	23	0.31	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	3	0.34	Functional ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	155	0.27	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Rattus norvegicus (OPRD_RAT) Mus musculus (OPRD_MOUSE)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Mus musculus (OPRD_MOUSE) Rattus norvegicus (OPRD_RAT)