| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 25th, 2009 | 34 | Yes |
Popular Name: DNC008022 DNC008022
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 7.33 | 15.51 | -18.99 | 0 | 4 | 0 | 60 | 442.47 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PA24A-2-E | Cytosolic Phospholipase A2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 6000 | 0.22 | Binding ≤ 10μM |
| PA2GA-1-E | Phospholipase A2, Membrane Associated (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3000 | 0.23 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PA24A_HUMAN | P47712 | Cytosolic Phospholipase A2, Human | 6000 | 0.22 | Binding ≤ 10μM |
| PA2GA_HUMAN | P14555 | Phospholipase A2 Group IIA, Human | 3000 | 0.23 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Acyl chain remodeling of CL | |
| Acyl chain remodelling of PC | |
| Acyl chain remodelling of PE | |
| Acyl chain remodelling of PG | |
| Acyl chain remodelling of PI | |
| Acyl chain remodelling of PS | |
| ADP signalling through P2Y purinoceptor 1 | |
| Arachidonic acid metabolism | |
| Hydrolysis of LPC | |
| phospho-PLA2 pathway | |
| Platelet sensitization by LDL | |
| Synthesis of PA |
