Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.21	12.44	-64.1	4	7	1	97	519.641	9	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.21	12.11	-23.32	3	7	0	96	518.633	9	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
MC3R-1-E	Melanocortin Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	727	0.23	Binding ≤ 10μM
MC4R-1-E	Melanocortin Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	76	0.26	Binding ≤ 10μM
MSHR-1-E	Melanocortin Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	10000	0.18	Binding ≤ 10μM
MC3R-1-E	Melanocortin Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	149	0.25	Functional ≤ 10μM
MC4R-1-E	Melanocortin Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.28	Functional ≤ 10μM
MSHR-1-E	Melanocortin Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1505	0.21	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	727	0.23	Binding ≤ 1μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	76	0.26	Binding ≤ 1μM
MSHR_HUMAN	Q01726	Melanocortin Receptor 1, Human	10000	0.18	Binding ≤ 10μM
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	727	0.23	Binding ≤ 10μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	76	0.26	Binding ≤ 10μM
MSHR_HUMAN	Q01726	Melanocortin Receptor 1, Human	1505	0.21	Functional ≤ 10μM
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	149	0.25	Functional ≤ 10μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	28	0.28	Functional ≤ 10μM